Hodgkin Lymphoma Flashcards
1
Q
is HL easy to treat?
A
70% of cases can be cured with first line therapy
2
Q
age distribution for HL
A
is bimodal. 20-24 and 75-79
3
Q
list the types of HL
A
nodular lymphocyte predominant
- nodular sclerosis CHL
- lymphocyte rich CHL
- mixed cellularity CHL
- lymphocyte depletion CHL
4
Q
how to reed steinberg cells escape the immune system
A
- overexpress PDL1/2
- down regulate HLA 1
- M2 polarization
- overexpress fas ligand
5
Q
how do we diagnose HL
A
with excisional or core biopsy of an entire lymph node.
- Use Ann harbor staging
6
Q
pathogenesis of HL
A
there is an activating mutation in NF-KB due to EBV allowing rapid and uncontrolled proliferation
7
Q
symptoms of HL
A
- B symptoms
- itching
- mediastinal masses causing resp difficulty
- alchohol induces pain in the lymph nodes
8
Q
therapy of CHL
A
ABVD - adriamycin, bleomycin, vinblastine, dacarbazine
- in case of relapse HSCT
9
Q
post therapy consequences of CHL
A
- Secondary MDS/AML from alkylating agents
- Solid tumors in breast and lung
- Pulmonary fibrosis from bleomycin
- Ischemic heart disease from doxorubicin
- Infertility from alkylating agents
10
Q
brentuxamab is
A
anti CD30
