Acute Lymphoblastic Leukemia Flashcards
1
Q
signs on CBC of ALL
A
cytopenia, thrombocyopenia, leukopenia, anemia.
2
Q
are the spleen or lymph nodes involved in ALL
A
yes
3
Q
classification of ALL based on morphology
A
type 1: small cells
type 2: blasts with increased size
type 3: blasts with vacuolization
4
Q
T cell lineage have which markers
A
CD7, CD2, Tdt
5
Q
B cell lineage have which markers
A
CD19, CD10. Tdt
6
Q
the more immature the status of the T/B cells
A
the worse the prognosis (T(8,14), t(4,11))
7
Q
very high risk ALL is characterised by
A
presence of philadelphia chromosome (CH9,22)
8
Q
therapy for ALL
A
imatinib mesylate (a competitive inhibitor for ATP binding site)
