Specific Immune Responses

Question 1

Which immunoglobulins are involved in Type II hypersensitivity reactions?

Answer 1

IgG, IgM - also complement

Question 2

Give examples of Type II hypersensitivity reactions

Answer 2

Goodpasture’s, hemolytic anemia, Graves’ disease

Question 3

Which immunoglobulin is involved in Type III hypersensitivity reactions?

Answer 3

IgG - also complement

Question 4

Give examples of Type III hypersensitivity reactions

Answer 4

SLE, Glomerulonephritis, serum sickness

Question 5

Which cytokines drive production of IgE

Answer 5

IL-4, IL-13

Question 6

Angiotensin I can be converted to II by action of this enzyme during type I hypersens. reactions, which is responsible for hypotension

Answer 6

Chymase

Question 7

What are the effector functions of IgG?

Answer 7

opsonization (IgG1 and IgG3)
activation of complement
ADCC
neonatal immunity

Question 8

What is the effector function of IgM?

Answer 8

Activation of complement

Question 9

What is the effector function of IgA?

Answer 9

Mucosal immunity

infant immunity in breastmilk

Question 10

What is the effector function of IgE?

Answer 10

mucosal immunity

Question 11

What is the receptor that binds to IgG1 and IgG3 to activate ADCC?

Answer 11

FcγR1 (CD64)

Question 12

Which complement pathway is activated by antibody?

Answer 12

classical

Question 13

Which complement pathway is activated by microbial cell surfaces?

Answer 13

alternative

Question 14

All 3 complement pathways result in the production of what?

Answer 14

C3

Question 15

Which complement protein attaches to microbes?

Answer 15

C3b

Question 16

What are the receptors for C3b

Answer 16

CR1 (CD35)

Question 17

Which receptor on NK cells binds to clustered IgG to initiate ADCC?

Answer 17

FCγRIII (CD16)

Question 18

Isotype switching to IgA occurs in response to what cytokines?

Answer 18

TGFβ and IL-5

Question 19

Which receptor transfers IgA into the lumen?

Answer 19

poly-Ig receptor

Question 20

Positively charged immune complexes tend to deposit in the basement membrane of which organs?

Answer 20

Skin

Kidney

Question 21

Describe the arthus reaction

Answer 21

antigen is injected into tissue of an immunized person leading to local edema, neutrophil migration, hemorrhage and necrosis

Question 22

When is the peak intensity of an arthus reaction after exposure to antigen?

Answer 22

4-10 hours

Question 23

Describe serum sickness

Answer 23

exposure to antigen in UNimmunized person leads to antibody production and formation of complexes - deposits into skin, joints, kidneys, lungs - activates complement

Question 24

When does serum sickness occur after antigen exposure

Answer 24

4-10 days

Question 25

What is contained in CD8 T cell granules?

Answer 25

perforin

granzyme

Question 26

How do CD8 T cells kill target cells?

Answer 26

1. Perforin and granzyme

2. FasL on T cell binds to Fas on target cell inducing apoptosis