Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Tao Le A/I Board Review > Specific Immune Responses > Flashcards

Specific Immune Responses Flashcards

1
Q

Which immunoglobulins are involved in Type II hypersensitivity reactions?

A

IgG, IgM - also complement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Give examples of Type II hypersensitivity reactions

A

Goodpasture’s, hemolytic anemia, Graves’ disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which immunoglobulin is involved in Type III hypersensitivity reactions?

A

IgG - also complement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Give examples of Type III hypersensitivity reactions

A

SLE, Glomerulonephritis, serum sickness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which cytokines drive production of IgE

A

IL-4, IL-13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Angiotensin I can be converted to II by action of this enzyme during type I hypersens. reactions, which is responsible for hypotension

A

Chymase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the effector functions of IgG?

A

opsonization (IgG1 and IgG3)
activation of complement
ADCC
neonatal immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the effector function of IgM?

A

Activation of complement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the effector function of IgA?

A

Mucosal immunity

infant immunity in breastmilk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the effector function of IgE?

A

mucosal immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the receptor that binds to IgG1 and IgG3 to activate ADCC?

A

FcγR1 (CD64)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which complement pathway is activated by antibody?

A

classical

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which complement pathway is activated by microbial cell surfaces?

A

alternative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

All 3 complement pathways result in the production of what?

A

C3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which complement protein attaches to microbes?

A

C3b

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the receptors for C3b

A

CR1 (CD35)

17
Q

Which receptor on NK cells binds to clustered IgG to initiate ADCC?

A

FCγRIII (CD16)

18
Q

Isotype switching to IgA occurs in response to what cytokines?

A

TGFβ and IL-5

19
Q

Which receptor transfers IgA into the lumen?

A

poly-Ig receptor

20
Q

Positively charged immune complexes tend to deposit in the basement membrane of which organs?

A

Skin

Kidney

21
Q

Describe the arthus reaction

A

antigen is injected into tissue of an immunized person leading to local edema, neutrophil migration, hemorrhage and necrosis

22
Q

When is the peak intensity of an arthus reaction after exposure to antigen?

A

4-10 hours

23
Q

Describe serum sickness

A

exposure to antigen in UNimmunized person leads to antibody production and formation of complexes - deposits into skin, joints, kidneys, lungs - activates complement

24
Q

When does serum sickness occur after antigen exposure

A

4-10 days

25
Q

What is contained in CD8 T cell granules?

A

perforin

granzyme

26
Q

How do CD8 T cells kill target cells?

A
  1. Perforin and granzyme

2. FasL on T cell binds to Fas on target cell inducing apoptosis

Tao Le A/I Board Review (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions