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Specialty Flashcards

1
Q

Benlysta

A

Belimumab

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2
Q

Benlysta MOA

A

Inhibits B cell activation

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3
Q

Benlysta indication

A

Lupus

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4
Q

Benlysta typical dosing
Oral:
Self injection:

A

Twice daily
Once weekly SQ

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5
Q

How long for results with Benlysta?

A

7 months

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6
Q

Benlysta 5 common side effects

A

Nausea, diarrhea, fever, cough, sore throat, runny nose, insomnia, pain, depression, headache, itching.

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7
Q

Cetrotide

A

Cetrorelix

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8
Q

Cetrotide MOA

A

GNRH antagonist that delays ovulation for egg retrieval procedure

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9
Q

Cetrorelix route and frequency

A

SQ daily

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10
Q

Cetrorelix 2 common side effects

A

Headache, nausea

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11
Q

Avonex

A

Rebif

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12
Q

Avonex MOA

A

Interferon

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13
Q

Avonex indication

A

multiple sclerosis

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14
Q

Avonex admin route

A

IM

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15
Q

Rebif admin route

A

Sub Q every 48 hours

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16
Q

Tocilizumab

A

Actemra

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17
Q

Actemra

A

Tocilizumab

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18
Q

Actemra MOA

A

IL-6 antagonist

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19
Q

Actemra indication

A

Rheumatoid arthritis

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20
Q

Actemra SQ admin

A

Allow to reach room temp 30 min syringe, 45 min autoinjector

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21
Q

What should Actemra solution look like?

A

Clear to pale yellow

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22
Q

Cosentyx

A

Secukinumab

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23
Q

Cosentyx MOA and indication

A

IL-17 antagonist in psoriasis and psoriatic arthritis

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24
Q

Cosentyx admin

A

Sub Q Allow to reach room temp 15 minutes sensoready pen or 30 minutes unoready pen.

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25
Q

Where to inject Cosentyx?

A

Front thigh, Lower abdomen, outer upper arms

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26
Q

Cosentyx 2 common side effects

A

Infection and sinus infection

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27
Q

Fasenra

A

Benralizumab

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28
Q

Benralizumab

A

Fasenra

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29
Q

Benralizumab MOA and indication

A

IL-5 antagonist, reduces survival of eosinophils and basophils, asthma

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30
Q

Fasenra admin

A

Allow to come to room temp for 30 minutes

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31
Q

Fasenra route

A

Sub Q, upper arm, thigh, or abdomen.

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32
Q

Leukeran

A

Chlorambucil

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33
Q

Chlorambucil

A

Leukeran

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34
Q

Leukeran MOA and indication

A

DNA alkylator, cancer

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35
Q

Leukeran 3 common side effects

A

Rash, blood dyscrasia’s, hepatotoxicity, pneumonitis

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36
Q

Kevzara

A

Sarilumab

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37
Q

Sarilumab

A

Kevzara

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38
Q

Kevzara MOA and indication

A

IL-6 antagonist, rheumatoid arthritis and psoriatic arthritis

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39
Q

Kevzara route

A

Sub Q thigh, abdomen, upper arm. Pre filled syringe warm for 30 minutes, pre filled pen warm for 60 minutes.

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40
Q

Kevzara appearance

A

Clear to pale yellow

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41
Q

Common side effects kevzara

A

Elevated AST /ALT, respiratory infection, UTI

42
Q

Enbrel

A

Etanercept

43
Q

Etanercept

44
Q

Enbrel MOA and indication

A

TNF blocker for rheumatoid and psoriatic arthritis

45
Q

Enbrel common side effects

A

Infection, rash, headache

46
Q

Enbrel admin

A

Let autoinjector come to room temp for 30 min, sub Q in thigh, upper arm, or abdomen

47
Q

Mekinist

A

Trametinib

48
Q

Trametinib

49
Q

Mekinist MOA and indication

A

Kinase inhibitor (targeted at cancer specific kinases that slows or stops growth of cancer cells)

50
Q

Mekinist common side effects

A

Rash, diarrhea, nausea, fatigue, lymphedema

51
Q

Trametinib admin

A

With small meal

52
Q

Pregnyl

A

Chorionic gonadotropin

53
Q

Pregnyl MOA

A

Induce ovulation and increase sperm count in men

54
Q

Chorionic gonadotropin

55
Q

Pregnyl common side effects

A

Bloating, stomach pain

56
Q

Pregnyl admin

A

Reconstitute, give IM in buttocks upper right quadrant.

57
Q

Crinone

A

Progesterone

58
Q

Crinone route

59
Q

Crinone indication

A

Abnormal uterine bleeding, infertility

60
Q

Crinone common side effects

A

Bloating, abd pain, cramps, sleepy, mood swings, breast pain

61
Q

Tasigna

62
Q

Nilotinib

63
Q

Nilotinib indication

64
Q

Common Tasigna side effects

A

Swelling, balding, night sweats, itching, rash, electrolyte discrepancy, high cholesterol and triglycerides, abd pain, all GI, myalgia, cough, URTI, fatigue

65
Q

Erleada

A

Apalutamide

66
Q

Apalutamide

67
Q

Erleada MOA and indication

A

Androgen receptor antagonist, Prostate cancer

68
Q

Erleada common side effects

A

HTN, swelling, rash, flushing, weight loss, nausea, diarrhea, joint pain, fatigue

69
Q

Gleostine

70
Q

Lomustin

71
Q

Gleostine indication and MOA

A

Cancer, alkylating agent

72
Q

Xeloda

A

Capecitabine

73
Q

capecitabine

74
Q

Cytoxan

A

Cyclophosphamide

75
Q

Cyclophosphamide

76
Q

Cytoxan indication

77
Q

Casodex

A

Bicalutamide

78
Q

Bicalutamide

79
Q

Casodex indication

A

Prostate cancer

80
Q

Casodex MOA

A

Anti androgen for cancer

81
Q

Evenity

A

Romosozumab

82
Q

Romosozumab

83
Q

Evenity MOA

A

Sclerostin inhibitor, increases bone formation and slightly decreases bone resorption

84
Q

Evenity common side effects

A

Joint pain, headache

85
Q

Evenity admin

A

2 shots sub Q every month

86
Q

Romosozumab boxed warnings

A

Increased risk of MI, stroke, and cardiovascular death

87
Q

Evenity storage and handling

A

Refrigerate, may be at room temp for 30 days

88
Q

What supplements needed while on Evenity?

A

Calcium and vitamin D

89
Q

Myfembree

A

Relugolix-estradiol-norethindrone

90
Q

Relugolix-estradiol-norethindrone

91
Q

Myfembree MOA and indication

A

Relugolix: reduces FSH and LH to decrease bleeding from uterine fibroids and pain from endometriosis
Estradiol: reduces bone loss from relugolix
Norethindrone: protects from endometrial cancer from estradiol
Indication: heavy menstrual bleeding in premenopausal women from uterine fibroids and pain with endometriosis

92
Q

Myfembree boxed warning

A

Clot risk, especially women over 35 who smoke or have uncontrolled HTN

93
Q

Myfembree common side effects

A

Hot flashes, sweating, abnormal vaginal bleeding, alopecia, decreased sexual interest

94
Q

Anagrelide

95
Q

Agrylin

A

Anagrelide

96
Q

Anagrelide moa

A

Reduces platelet count by reduced survival of megakaryocytes

97
Q

Anagrelide indication

A

Thrombocytopenia secondary to neoplasms to reduce clot risk.

98
Q

Anagrelide common side effects

A

Heart: chest pain, palpitations, edema
GI: abd pain, NVD
CNS: dizzy, headache, pain, weakness
Respiratory: dyspnea

99
Q

Anagrelide max daily dose

A

10 mg or 2.5 mg qid

100
Q

Inflectra

A

Infliximab

101
Q

Why is zymfentra not interchangable with remicade or inflectra?

A

It is given sub q rather than IV

Pharmacy (22 decks)

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