NMJ Agents, Antispasmodics, And Nicotine

Question 1

Nicotine ganglionic blockade MOA:

Effects: heart, eyes, mouth, sweat glands, and blood pressure

Answer 1

Stimulates nicotinic receptors to the point of blockage as it causes persistent depolarization.
Activating: tachycardia, mydriasis, xerostomia, anhidrosis, hypotension.

Question 2

What can happen if alcohol consumed when taking varenicline?

Answer 2

Seizures

Question 3

Dantrolene MOA

Answer 3

Inhibits release of calcium from sarcoplasmic reticulum, preventing muscles from contracting as much.