Muscarinic Receptor Agonists And Antagonists Flashcards
What drug class is Pilocarpine?
Muscarinic agonist
Pilocarpine indications, topically and systemically
Topically: glaucoma
Systemically: dry mouth
Muscarinic agonist side effects
Salivation, lacrimation, urination, defecation. Vision problems, nausea, bronchospasm
Cevimeline indication
Dry mouth
Which are Muscarinic antagonists?
Atropine, cevimeline, scopolamine, ipratropium, pilocarpine, oxybutynin
Atropine, scopolamine, ipratropium, and oxybutynin
2 Atropine indications
Acute symptomatic bradycardia and aspiration prophylaxis
3 unique Scopolamine side effects
Drowsiness, amnesia, and fatigue
Anti Muscarinic eye drop effects
Mydriasis
Why do the anti Muscarinic COPD agents have less side effects?
Lower absorption as quarternary amines
Why would an agent (trospium or tolterodine) other than oxybutynin be used in incontinence?
Less CNS effects
Glycopyrrolate 2 indications
Duodenal ulcer and drooling
Glycopyrrolate chemical basis for lack of certain adverse effects
Quarternary amine: minimal CNS effects
Trihexyphenidyl and benztropine indication
Tremor in Parkinson’s
How to treat urinary incontinence in males with BPH
Treat BPH, Muscarinic antagonists contraindicated
