special endocytosis

Question 1

once LDL has fused into clathrin coated vesicle from exoplasmic side, what does it first fuse with on cytosolic side?

Answer 1

early endosome

Question 2

what pathway does LDL follow?

Answer 2

vesicle, early endosome, late endosome, endolysosome, hydrolytic enzymes release cholesterol into cytosol

Question 3

what is cholesterol critical for?

Answer 3

the formation of healthy cell membranes.

Question 4

where is cholesterol obtained?

Answer 4

from diet, and it is synthesized by human body

Question 5

LDLs

Answer 5

low density lipoproteins. form in which cholesterol is transported around the body

Question 6

what does a cell do when it needs cholesterol?

Answer 6

it produces LDL receptors on its surface. LDL receptors bind circulating LDLs.

Question 7

what do LDL receptors do on cytoplasmic side of the cell membrane?

Answer 7

receptors bind to adaptins, which in turn bind to clathrin.

Question 8

how does LDL enter cell?

Answer 8

receptor mediated endocytosis

Question 9

where does LDL dissociate from its recepor?

Answer 9

in the endosomal environment

Question 10

what happens to LDL receptor proteins after they have delivered LDL?

Answer 10

they are returned to plasma membrane using transport vesicles that bud off from early endosomes