Endoplasmic Reticulum: part I

Question 1

exoplasmic side of ER

Answer 1

inside?

Question 2

exoplasmic is continuous with

Answer 2

topoligically continous with the outside of the cell

Question 3

cis Golgi

Answer 3

forming part of golgi

Question 4

three parts of golgi

Answer 4

cis, golgi, medial golgi, trans golgi

Question 5

nucleus has two membranes

Answer 5

inner nuclear and outer nuclear

Question 6

what does ER membrane create

Answer 6

continuouis lumenal compartment, with rough and smooth regions

Question 7

functions of the ER

Answer 7

lipid synthesis, exchange and movement
detoxification of lipid soluble compounds
calcium sequestration
protein synthesis and processing

Question 8

where are phospholipids synthesized

Answer 8

on the cytosolic face of the ER membrane

Question 9

how are phospholipids made on cytosolic side moved over to the lumenal side

Answer 9

flippase

Question 10

why is scramblase needed

Answer 10

they catalyze filipping of phospholipid to exosolic surface

Question 11

role of smooth ER

Answer 11

detoxifies lipid-soluble compounds, like drugs, insecticides, petroleum products, carcinogens. catalyzed by. turned into water soluble compound. catalyzed by cytochrome p450 proteins

Question 12

ER and intracellular calcium

Answer 12

calcium maintained in ER structures;

expanded ER is sarcoplasmic reticulum in muscles;

Question 13

lipid droplet formation

Answer 13

ER is now known to have lipid droplet formation

Question 14

ER and peroxisomes

Answer 14

ER contributes to the creation of peroxisomes

Question 15

example of cell engaged in detoxification

Answer 15

hepatocytes, which also produce lipoprotein particles that carry lipid in the blood. have significant amounts of smooth ER

Question 16

How does ER membrane transport calcium from the cytosol?

Answer 16

actively. generates a high concentration of calcium ions in the ER lumen and maintains low ion concentration in the cytosol