clinical consequences Flashcards
1
Q
what is makeup of low density lipoprotein?
A
core: 1500 cholesterol ester molecules
outer monolayer: 800 phospholipid + 500 cholesterol molecules
apolipoprotein B-100
2
Q
what happens if cholesterol accumulates at high levels in the blood?
A
it can result in the deposition of lipid and fibrous tissue in blood vessels
3
Q
atherosclerotic phaques
A
deposits of lipid and fibrous tissue in blood vessels. can lead to severe cardiovascular disease and early death from hearth attack.
4
Q
how can LDL receptor defect cause familial hypercholesterolemia?
A
they can lack the cytoplasmic portion that binds to adaptins in the clathrin-coatedpits
5
Q
consequence of receptors that can’t bind adaptin?
A
LDL can’t be endocytosed into cell. remains in the blood circulation.
