caveolae

Question 1

what is a caveolin

Answer 1

a self-assembling, integral membrane protein family with a high affinity for binding cholesterol.

Question 2

what are caveoli

Answer 2

cholesterol and glycolipid rich regions, a specialized subset of plasma membrane asociated lipid rafts

Question 3

what can be concentrated in caveolae? what functions does this suggest?g

Answer 3

gpi anchored plasma membrane proteins, which include many membrane receptors and signaling molecules, can be concentrated in caveolae, suggesting functions in signal transduction.

Question 4

what caveolae form?

Answer 4

endocytic vesicles by budding from the PM (also using dynamin to pinch off)

Question 5

what roles are indicated for the caveolae pathway?

Answer 5

transcytosis and delivery to an endosomal type of compartment

Question 6

what does retrograde transport to the ER represent?

Answer 6

one pathway from which endocytosed molecules could be reverse transported into the cytosol through the translocon.

Question 7

What viruses use caveoli? how?

Answer 7

SV40 and papilloma virus use caveoli to enter cells and from there make their way to the ER through specialized endosomes.

Question 8

where are cavewolae prominent?

Answer 8

endothelial cells

Question 9

what kind of texture does cytosoolic face of caveolae membrane have?

Answer 9

cauliflower, which is thought to result from aggregates of caveolin in the membrane