Some cancer stuff

Question 1

What cancers are associated with excess active vitamin D → hypercalcemia?

Answer 1

Hodgkin lymphoma

Some non-Hodgkin lymphomas

Question 2

What cancer is associated with excess ACTH → Cushing syndrome?

Answer 2

Small cell lung carcinoma

Question 3

Besides excess ACTH, what other hormone can be secreted by small cell lung cancer? What other neoplasms can secrete this hormone?

Answer 3

Small cell lung carcinoma and intracranial neoplasms can cause excess ADH → SIADH

Question 4

What antibodies can be released from small cell lung carcinoma?

Answer 4

Antibodies against presynaptic Ca2+ channels at NMJ → Lambert-Eaton myasthenic syndrome

Question 5

So to recap, what can all possibly be secreted by small cell lung carcinomas?

Answer 5

ACTH
ADH
Antibodies against presynaptic Ca2+ channels at NMJ

Question 6

What cancers can cause polycythemia?

Answer 6

“P-otentially R-eally H-igh H-ematocrit”

Pheochromocytoma
Renal Cell Carcinoma
Hepatocellular carcinoma
Hemangioblastoma

(leiomyoma and thymoma via first-aid)

Question 7

What cancers can secrete PTHrP → hypercalcemia?

Answer 7

Squamous cell carcinoma
Renal Cell Carcinoma
Breast cancer

Question 8

What four neoplasms should be considered when psammoma bodies are seen?

Answer 8

PSaMMoMa

P-apillary carcinoma of thyroid
S-erous papillary cystadenocarcinoma of ovary
M-alignant M-esothelioma
M-eningioma

Question 9

What tumors metastasize to the liver?

Answer 9

“C-ancer S-ometimes P-enetrates B-enign L-iver”

C-olon
S-tomach
P-ancreatic
B-reast
L-ung

Question 10

What tumors metastasize to the brain?

Answer 10

“L-ots of B-ad S-tuff K-ills G-lia”

L-ung
B-reast
S-kin (mesothelioma)
K-idney (RCC)
G-I tract (CRC)

Question 11

What tumors metastasize to bone?

Answer 11

“P-ermanently R-elocated T-umors L-ike B-one”

P-rostate
R-CC
T-estes/T-hyroid
L-ung
B-reast