Antipsychotics Flashcards
What are the low-potency typical antipsychotics?
Chlorpromazine
Thioridazine
What is the side effect seen with chlorpromazine or thioridazine?
Anticholinergic effects
What is the major action of low-potency typical antipsychotics? What other receptors does it block?
Blocks D2
Blocks muscarinic, alpha1, and H1 receptors
What are the high-potency typical antipsychotics?
Haloperidol Fluphenazine Loxapine Thithixene Trifluroperazine
What side effects are often seen with high-potency typical antipsychotics?
Extrapyramidal symptoms
Neuroleptic Malignant Syndrome (NMS)
Tardive dyskinesia (seen with longterm use)
Fewer anticholinergic side effects
What are the symptoms of NMS?
Delirium Autonomic instability Muscle rigidity Myoglobinuria Hyperpyrexia
How is NMS treated?
Dantrolene
Bromocriptine
What are the benefits of using atypical antipsychotics?
Fewer EPS or anticholinergic side effects
Have more of an effect on negative symptoms than typicals do
What side effect is seen with atypical antipsychotics that isn’t seen with typicals?
Weight gain
What are the primary sites of action of atypicals? What other receptors are blocked?
Block dopamine and serotonin receptors
Also block alpha and H receptors
What are the atypical antipsychotics?
Qlanzepine Quetiapine Risperidone Aripiprazole Clozapine
What is the most potent of the atypicals?
Clozapine
Is clozapine commonly used?
No. Clozapine causes agranulocytosis
