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PMP 102 > Solubility Of Weak Acids And Bases > Flashcards

Solubility Of Weak Acids And Bases Flashcards

1
Q

What is the solubility of weak acids and bases influenced by?

A

pH

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2
Q

Weakly acidic drugs have a greater aqueous solubility at what pH values?

A

Higher

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3
Q

Weakly basic drugs have a greater aqueous solubility at what pH values?

A

Lower

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4
Q

How to determine the pH of weakly acidic drugs?

A

pH=pKa+log [A-]
[HA]

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5
Q

How to determine the pH of weakly basic drugs?

A

pH=pKa +log[B]
[BH+]

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6
Q

What makes an amphoteric drug?

A

Both acidic and basic groups

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7
Q

When are amphoteric drugs ionised?

A

At all pH values.

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8
Q

what aqueous solubility will weakly acidic drugs have at higher pH?

A

greater aqueoius solubility

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9
Q

what aqueous solubility will weakly basic drugs have at lower pH?

A

greater aqueous value

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10
Q

when there is no net charge what will amphoteric drugs show?

A

solubility minimum
isoelectric point

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PMP 102 (29 decks)

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