Journey From Molecule To Medicines

Question 1

What is the definition of good target?

Answer 1

Manipulation by the drug can provide a therapeutic benefit with an acceptable safety window.

Question 2

What is the definition of hit compound?

Answer 2

Molecule that shows the desired type of screening assay.

Question 3

What is the definition of assay?

Answer 3

Test systems that evaluate the effect of the new drug candidate.

Question 4

What is the definition of lead compound?

Answer 4

Compound that shows promise as a treatment for a disease and may lend to development of a new drug.

Question 5

Main stages of the drug development process…

Answer 5

Discovery and development
Preclinical research
Clinical development
Review
Post-marketing monitoring

Question 6

The stages of drug discovery and development…

Answer 6

Basic research
1) target identification
2) target validation
Early discovery
1) hit discovery process and assay development
2) hit to lead process and lead optimisation

Question 7

The phases of clinical development…

Answer 7

Phase 1: 100 healthy volunteers (66.4%)
Phase 2: 100-500 patients with the disease (58.3%)
Phase 3: 1000-5000 patients with the disease (59%)