SNS Blockers Alpha & Beta

Question 1

What is the action?

Answer 1

Blocks norepinephrine at all alpha & beta receptors in the SNS
↓ BP & HR
↑ renal perfusion
↓ Renin

Question 2

SNS blockers Alpha & beta drug names?

Answer 2

Carvedilol

Labetalol

Question 3

What are the contraindications/cautions?

Answer 3

Allergy
Heart block (beta cell blocked ↓ HR)
Bradycardia (beta cell blocked ↓ HR)
Lung disease/bronchospasm (block beta 2 receptors)
Diabetics (alteration in glucose)

Question 4

What are the drug-drug interactions (DDI)?

Answer 4

Antidiabetic agents (↑ the effectiveness of these drug)
when given w/calcium channel blockers (electrical system problems within heart)

Question 5

What are the indications (use for)?

Answer 5

HTN

Question 6

What are the adverse effects?

Answer 6

CNS: Fatigue, HA, Dizziness, memory loss, insomnia, disorientation
CV: Arrhythmias & hypotension
Pulmonary: bronchospasm, cough, laryngospasm, pulmonary edema
GI effects: N & V, diarrhea
GU effects: Impotence, hypoglycemia, rash

Question 7

What are the nursing implications?

Answer 7

Do not stop abruptly (can cause MI, stroke, or arrthymias)
Ineffective clearance r/t lack of bronchodilating effects
Hx: contraindication/cautions
CNS: cardiac, respiratory, abdominal, urinary, perfusion
Vitals, ECG
Labs: electrolytes, renal/hepatic function, glucose
Take apical pulse; hold if below 60
Monitor blood glucose
Lifestyle changes
change position slowly
Do not crush extended-release formulations