SNS Alpha-Adrenergic Blocker (non-selective)

Question 1

What is the action?

Answer 1

Block alpha 1 receptors
vasodilation = ↓ BP
Blocks alpha 2 receptors
prevents norepinephrine feedback loop = ↑ reflex tachycardia

Question 2

SNS Alpha-Adrenergic blocker non-selective drug names?

Hint: “phen & amine”

Answer 2

Phenoxybenzamine

Phentolamine (more common)

Question 3

What are the contraindications/caution?

Answer 3

Allergy
CAD
MI

Question 4

What are the drug-drug interactions (DDI)?

Answer 4

Alcohol

Question 5

What is the indications (use for)?

Answer 5

Dx & manage episodes of pheochromocytoma

Pheochromocytoma (rare condition); benign tumor in the adrenal gland; too many hormones = ↑ BP

Question 6

What are the adverse effects?

Answer 6

↑ reflex tachycardia
GI effects: N & V, diarrhea, abdominal pain
CNS: Headache, weakness, & dizziness
related to vasodilation & ↓ BP; hypotension, flushing, arrhythmia & angina

Question 7

What are the nursing implications?

Answer 7

Hx: contraindications/cautions
CNS: cardiac, respiratory, abdominal, urinary, perfusion
Vitals, ECG
Labs: electrolytes, renal/hepatic function, glucose
Take apical pulse; hold if below 60bpm
Monitor blood glucose
lifestyle changes
change position slowly
Do not crush extended-release formulations