SNS Alpha 2 Agonist

Question 1

What is the action?

Answer 1

Stimulate the alpha receptors in the CNS & inhibits CV centers
↓ sympathetic outflow from the CNS = drop in BP

Question 2

SNS Alpha 2 Agonist drug name?

Answer 2

Clonidine

Question 3

What are the drug-drug interaction (DDI)?

Answer 3

Beta blockers (paradoxical effect)
Adrenergic antagonists (↓ drug effectiveness)
CNS depressants/alcohol (↓ CNS outflow dangerous)

Question 4

What are the indications (use for)?

Answer 4

HTN

Question 5

What are the adverse effects?

Answer 5

CNS: Fatigue, Sedated, lethargy, drowsiness, dry eyes, dry mouth, bad dreams
CV: Hypotension, Heart failure, bradycardia

Question 6

What are the nursing implications?

Answer 6

Do not stop abruptly (rebound hypertension)
Given oral or transdermal for HTN
Hx: contraindication/cautions
CNS: cardiac, respiratory, abdominal, urinary, perfusion
Vitals, ECG
Labs: electrolytes, renal/hepatic function, glucose
Take apical pulse; hold if below 60
Monitor blood glucose
Lifestyle changes
change position slowly
Do not crush extended-release formulations