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Pulmonology > SM 167 Lung Pathology Tumors > Flashcards

SM 167 Lung Pathology Tumors Flashcards

1
Q

What is this?

A

Adenocarcinoma, due to lots glands

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2
Q

What are the three types of non small cell lung carcinoma?

A

Adenocarcinoma, squamous cell carcinoma, large cell carcinoma

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3
Q

What tumor effects the lung pleura?

A

Mesothelioma

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4
Q

What is the most common form of lung cancer in smokers?

A

Adenocarcinoma

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5
Q

What are driver mutations in adenocarcionma?

A

Mutations that determine the treatment used for the cancer

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6
Q

How does adenocarcinoma appear on pathology?

A

Gland formation, mucin production, and immunoreactive to TTF1

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7
Q

What tumor is immunoreactive to TTF1?

A

Adenocarcinoma

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8
Q

What is squamous cell carcinoma?

A

A central tumor with it’s own unique driver mutations, that has no mutation directed therapies

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9
Q

What does squamous cell carcinoma look like on pathology?

A

Keratinization, intracellular bridges, and TTF1 negative

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10
Q

What is this?

A

Squamous cell carcinoma, because it is large and central

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11
Q

What is this?

A

Squamous cell carcinoma, due to significant keratinization (pink)

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12
Q

What is this?

A

Squamous cell carcinoma, due to intracellular bridges/desmosomes

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13
Q

What defines large cell carcinoma?

A

Ironically, nothing - they’re just poorly differentiated tumors that are neither adenocarcinoma’s or squamous cell carcinoma’s

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14
Q

Which type of tumor is a wastebasket category of poorly differentiated tumors?

A

Large cell carcinoma’s

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15
Q

What are small cell carcinoma’s?

A

Almost invariably associated with smoking, generally unresectable and central

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16
Q

Are small cell carcinoma’s central or peripheral?

A

Small cell carcinoma is central, towards the mediastinum

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17
Q

Which type of carcinoma involves distant metastises?

A

Small cell carcinoma frequently has distant met’s

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18
Q

Does small cell carcinoma respond to chemo?

A

Initially yes, but very poor prognosis

19
Q

Which carcinoma demonstrates neuroendocrine differnetiation?

A

Two: small cell and carcinoids

20
Q

What does small cell carcinoma look like under pathology?

A

High nuclear:cytoplasmic ratio, mitotic figures, and dark chromatin

21
Q

What is this?

A

Small cell carcinoma, due to large nuclei:cytoplasm ratio and mitotic figures

22
Q

What tumor is not associated with smoking?

A

Carcinoid tumors

23
Q

Do carcinoid tumors metastisize?

A

Usually, Carcinoids are very indolent, but occassionally can metastisize

24
Q

Are Carcinoids central or peripheral?

A

Very central, often inside bronchi

25
Q

What do carcinoids look like under pathology?

A

Low nuclear:cytoplasmic ratio’s, salt and pepper chromatin

26
Q

What is this and why?

A

Carcinoid tumor, due to low nuclear:cytoplasm ratio and salt/pepper chromatin

27
Q

What are mesothelioma’s?

A

Malignant tumors that arise from mesothelial cells in pleural lining, associated with asbestos, and have a bad prognosis

28
Q

What is this?

A

Mesothelioma - hugs the border of the lung like the pleural lining

29
Q

What are the 3 components of the mediastinum?

A

Anterior, Middle, and Posterior Mediastinum

30
Q

What is found in the anterior mediastinum?

A

Thymus

31
Q

What is found in the middle mediastinum?

A

Heart, trachea, lymph nodes

32
Q

What is found in the posterior mediastinum?

A

Aorta, esophagus, sympathetic trunk

33
Q

What tissue is this?

A

Thymus

34
Q

What is a thyoma?

A

A tumor of low malignant potential associated with autoimmune paraneoplastic syndromes

35
Q

What is this?

A

Thyoma

36
Q

What is a thymic carcinoma?

A

A high grade malignany not associated with autoimmune paraneoplastic syndromes

37
Q

What tumors are found in the anterior mediastinum?

A

Thymoma, thymic carcinoma, germ cell tumors and lymphomas

38
Q

What tumor is found in the middle mediastinum?

A

Metastatic lung carcinoma

39
Q

What tumors are found in the posterior mediastinum?

A

Schwannoma, malignant peripheral nerve sheath tumors, and paragangliomas

40
Q

What are Schwannomas?

A

Bening tumors arising from the supporting cells of nerve roots

41
Q

What are malignant peripheral nerve sheath tumors?

A

Malignant tumors arising from nerve roots of supporting cells, not neurons

42
Q

What is a paraganglioma?

A

A tumor from the non-neural cells of the SNS with low malignant potential, forms nests of cells known as Zellballen

43
Q

What tumor is described as Zellballen?

A

Paraganglioma’s

Pulmonology (22 decks)

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