SM 167 Lung Pathology Tumors

Question 1

What is this?

Answer 1

Adenocarcinoma, due to lots glands

Question 2

What are the three types of non small cell lung carcinoma?

Answer 2

Adenocarcinoma, squamous cell carcinoma, large cell carcinoma

Question 3

What tumor effects the lung pleura?

Answer 3

Mesothelioma

Question 4

What is the most common form of lung cancer in smokers?

Answer 4

Adenocarcinoma

Question 5

What are driver mutations in adenocarcionma?

Answer 5

Mutations that determine the treatment used for the cancer

Question 6

How does adenocarcinoma appear on pathology?

Answer 6

Gland formation, mucin production, and immunoreactive to TTF1

Question 7

What tumor is immunoreactive to TTF1?

Answer 7

Adenocarcinoma

Question 8

What is squamous cell carcinoma?

Answer 8

A central tumor with it’s own unique driver mutations, that has no mutation directed therapies

Question 9

What does squamous cell carcinoma look like on pathology?

Answer 9

Keratinization, intracellular bridges, and TTF1 negative

Question 10

What is this?

Answer 10

Squamous cell carcinoma, because it is large and central

Question 11

What is this?

Answer 11

Squamous cell carcinoma, due to significant keratinization (pink)

Question 12

What is this?

Answer 12

Squamous cell carcinoma, due to intracellular bridges/desmosomes

Question 13

What defines large cell carcinoma?

Answer 13

Ironically, nothing - they’re just poorly differentiated tumors that are neither adenocarcinoma’s or squamous cell carcinoma’s

Question 14

Which type of tumor is a wastebasket category of poorly differentiated tumors?

Answer 14

Large cell carcinoma’s

Question 15

What are small cell carcinoma’s?

Answer 15

Almost invariably associated with smoking, generally unresectable and central

Question 16

Are small cell carcinoma’s central or peripheral?

Answer 16

Small cell carcinoma is central, towards the mediastinum

Question 17

Which type of carcinoma involves distant metastises?

Answer 17

Small cell carcinoma frequently has distant met’s

Question 18

Does small cell carcinoma respond to chemo?

Answer 18

Initially yes, but very poor prognosis

Question 19

Which carcinoma demonstrates neuroendocrine differnetiation?

Answer 19

Two: small cell and carcinoids

Question 20

What does small cell carcinoma look like under pathology?

Answer 20

High nuclear:cytoplasmic ratio, mitotic figures, and dark chromatin

Question 21

What is this?

Answer 21

Small cell carcinoma, due to large nuclei:cytoplasm ratio and mitotic figures

Question 22

What tumor is not associated with smoking?

Answer 22

Carcinoid tumors

Question 23

Do carcinoid tumors metastisize?

Answer 23

Usually, Carcinoids are very indolent, but occassionally can metastisize

Question 24

Are Carcinoids central or peripheral?

Answer 24

Very central, often inside bronchi

Question 25

What do carcinoids look like under pathology?

Answer 25

Low nuclear:cytoplasmic ratio's, salt and pepper chromatin

Question 26

What is this and why?

Answer 26

Carcinoid tumor, due to low nuclear:cytoplasm ratio and salt/pepper chromatin

Question 27

What are mesothelioma's?

Answer 27

Malignant tumors that arise from mesothelial cells in pleural lining, associated with asbestos, and have a bad prognosis

Question 28

What is this?

Answer 28

Mesothelioma - hugs the border of the lung like the pleural lining

Question 29

What are the 3 components of the mediastinum?

Answer 29

Anterior, Middle, and Posterior Mediastinum

Question 30

What is found in the anterior mediastinum?

Answer 30

Thymus

Question 31

What is found in the middle mediastinum?

Answer 31

Heart, trachea, lymph nodes

Question 32

What is found in the posterior mediastinum?

Answer 32

Aorta, esophagus, sympathetic trunk

Question 33

What tissue is this?

Answer 33

Thymus

Question 34

What is a thyoma?

Answer 34

A tumor of low malignant potential associated with autoimmune paraneoplastic syndromes

Question 35

What is this?

Answer 35

Thyoma

Question 36

What is a thymic carcinoma?

Answer 36

A high grade malignany not associated with autoimmune paraneoplastic syndromes

Question 37

What tumors are found in the anterior mediastinum?

Answer 37

Thymoma, thymic carcinoma, germ cell tumors and lymphomas

Question 38

What tumor is found in the middle mediastinum?

Answer 38

Metastatic lung carcinoma

Question 39

What tumors are found in the posterior mediastinum?

Answer 39

Schwannoma, malignant peripheral nerve sheath tumors, and paragangliomas

Question 40

What are Schwannomas?

Answer 40

Bening tumors arising from the supporting cells of nerve roots

Question 41

What are malignant peripheral nerve sheath tumors?

Answer 41

Malignant tumors arising from nerve roots of supporting cells, not neurons

Question 42

What is a paraganglioma?

Answer 42

A tumor from the non-neural cells of the SNS with low malignant potential, forms nests of cells known as Zellballen

Question 43

What tumor is described as Zellballen?

Answer 43

Paraganglioma's