Slow viruses and Prions

Question 1

Causes progressive multifocal leukoencephalopathy

Answer 1

JC virus

Polyoma

Question 2

Causes subacute sclerosing panencephalitis (Dawson’s)

Answer 2

Measles

persistent measles infection

Question 3

Clinical presentation of demyelination, vascular cuffing, gliosis, and infiltration of fat-laden macrophages near blood vessel walls

Answer 3

SSPE

Question 4

A large number of nucleocapsids are produced in the neurons and the glial cells. In these cells the viral genes that encode envelope proteins have restricted expression.

Answer 4

SSPE

Question 5

Infection of oligodendrocytes

Answer 5

PML - JC virus

Question 6

AIDS-defining disease according to CDC

Answer 6

PML

Question 7

Spongiform neurodegeneration

Answer 7

Prion diseases

Question 8

Familial forms of Creutzfeldt-Jakob disease have this gnee

Answer 8

PrPg ene

Question 9

Familial forms of CJD include:

Answer 9

Gertsmann-Straussler-Scheinker Syndrome

Fatal Familial Insomnia

Question 10

Protein diagnostic in CSF of CJD

Answer 10

14-3-3

Question 11

Cerebellar ataxia
Action tremor
Involuntary movements
Choreoathetosis
Myoclonic jerks
Coarse fasciculation

Answer 11

Kuru