RNA viruses II Flashcards

1
Q

TORCH infections

A
Toxoplasmosis
Other?
Rubella
CMV
HSV-2
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2
Q

Seeding of tissues by poliovirus

A

anterior horn cells

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3
Q

When are maximum titers achieved in polio infection

A

2-6 weeks after onset

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4
Q

Aseptic meningitis caused by what type of Coxsackie?

A

Group B
&
A7, A9

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5
Q

These viruses produce positive-sense DNA from negative-sense RNA

A

retroviruses

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6
Q

Cause WEE and EEE

A

alphavirus

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7
Q

High WBC in PBS.
Paraneoplastic syndrome characterized by bone resorption and hypercalcemia.

Most likely etiological agent?

A

HTLV-1

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8
Q

Most important receptor for Picorna

A

VCAM-1

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9
Q

Resembles mild rotavirus infection.

diarrhea in children.

A

astrovirus

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10
Q

Extensive paralysis and wasting.

Difficulty in swallowing, speaking, breathing.

A

Bulbar Polio

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11
Q

RNA virus causing common cold and SARS

A

Coronavirus

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12
Q

Carried by ixodid ticks

A

Mammalian tick-borne group of flavivirus

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13
Q

Acid-labile picornavirus

A

rhinovirus

therefore it does not infect GI like other picorna

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14
Q

Pharyngeal lesions + vesicular rashes on palms and soles spreading centrally?

A

Hand-foot-mouth disease

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15
Q

Alphavirus and Rubella are both

A

togaviruses

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16
Q

Depression of what complement component in DHF’s immune-complex hypersensitivity causes hemorrhages

A

C3

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17
Q

Causes adult T-cell leukemia/lymphoma

A

HTLV-1

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18
Q

Recrudescence of paralysis decades after initial manifestation

A

Progressive postpoliomyelitis muscle atrophy

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19
Q

Transmission of HCV

A

Blood

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20
Q

Causes congenital syndrome featuring microcephaly, PDA, cataracts

A

Rubella

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21
Q

Calicivirus causing epidemic viral gastroenteritis

A

Norwalk virus

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22
Q

Tick-borne flaviviruses cause

A

encephalitis

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23
Q
Chikungunya
Mayaro
O'nyong-nyong
Sindbis
Ross River

These are all types of _____ causing what symptoms?

A

alphaviruses

fever, rash, polyarthritis

These viruses are all vectorborne (arbo)

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24
Q

This RNA virus causes fever and thoracic pain aggravated by breathing

A

Epidemic Pleurodynia (Coxsackie B)

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25
Most common form of polio
Mild. Vague symptoms resembling other infections. Recovery in a few days.
26
Fever, postauricular lymphadenopathy, arthralgia, rash starts at head then descends.
Rubella
27
Hepatitis virus resembling calici morphology while resembling HAV clinical course
HEV is acute like HAV with no late hepatic sequelae and no evidence of chronic infection
28
Fever, black vomitus, jaundice. Most likely virus?
Yellow fever
29
Bornholm Disease or The Devil's Grip is AKA? What specific virus?
Epidemic pleurodynia Coxsackie B
30
Viruses associated with Culex?
West Nile | St. Louis
31
Viruses associated with Aedes?
Dengue | Yellow Fever
32
RNA virus that replicates in mature villus epithelial cells of small intestine. Enterotoxin induces age- and calcium ion-dependent chloride secretion, disrupts SGLT1 transporter-mediated reabsorption of water, and apparently reduces activity of brush-border membrane disaccharidases.
rotavirus
33
Myocarditis can be caused by which Coxsackie virus?
Group B
34
German measles is aka
rubella
35
This RNA virus causes Hand-foot-mouth
Coxsackie A16
36
Enterovirus 68 causes
bronchiolitis/pneumonia in children | RSV and metapneumo as well
37
Enterovirus 70 causes
acute hemorrhagic conjunctivitis | Coxsackie as well
38
Enterovirus 71 causes
meningitis, encephalitis
39
Coxsackie A24 can cause this eye disease in large outbreaks
acute hemorrhagic conjunctivitis
40
Has three transmission cycles: Sylvatic/jungle Urban Intermediate
Yellow fever virus
41
Result of sequential heterogenous infection causes a severe hemorrhagic fever due to immune complex hypersensitivity reaction
Dengue
42
Echovirus reclassification: 10 22, 23 28
Reo Type 1 Parecho 1, 2 Rhino 1A
43
Fever, jaundice, elevated ALT > elevated AST are signs of what (general)
hepatitis (all viruses)
44
Picornavirus that causes acute viral hepatitis
HAV
45
Gene order for all retroviruses
5'gag-pro-pol-env-3'
46
Cellular receptor for HIV?
CD4 (on T cells)
47
Retrovirus gene encoding for core proteins
gag
48
WBC that can serve as reservoirs of HIV infection
monocyte-lineage cells
49
Retrovirus gene encoding for protease
pro
50
HIV has the ability to bind to this receptor of dendritic cells
C-type lectin receptors | particularly DC-SIGN
51
Retrovirus gene encoding for reverse transcriptase
pol (POLymerase)
52
RNA virus that stains green-yellow with acridine orange (like DNA)
Reovirus RNA stain red
53
Retrovirus gene encoding for non-structural protein that alters transcription efficiency of other genes
tax | tat
54
Retrovirus gene encoding for glycoprotein projections
env (on ENVelope)
55
Reovirus that causes enteritis in children and infants
Orthoreovirus
56
This RNA virus causes Herpangina or vesicular pharyngitis
Coxsackie A Sudden fever, headache, sore throat, dysphagia
57
ECHO in echovirus stands for what?
Enteric cytopathogenic human onrphan
58
Orbivirus family? Vector
Reovirus | Tick
59
Common cold, URT symptoms
rhinovirus
60
Colorado tick fever
Coltovirus | COLorado Tick fever - most important tick-borne pathogen in USA
61
Activation of latent HIV-infected cells can be induced by what cytokines?
TNF | IL-6
62
Rotavirus is the most important:
global cause of infantile gastroenteritis and severe diarrhea in the world
63
First antibodies detected against HIV?
anti-gp41
64
Malignancies associated with HIV:
Kaposi's sarcoma Non-Hodgkin's B cell lymphoma Carcinoma of rectum and tongue
65
Group of rotaviruses causing outbreaks in developed or developing countries? Most common
Group A
66
Viral protein of rotavirus responsible for pathogenicity as a stimulator of diarrhea
NSP4 | non-structural protein 4
67
HAV transmission
feco-oral