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3 Micro > Oncogenic viruses > Flashcards

Oncogenic viruses Flashcards

1
Q

***What virus uses CD4, CXCR4, CCR5?

A

HIV

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2
Q

What virus uses CD21 (complement receptor 2)

A

EBV

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3
Q

***What virus uses CD46 and SLAM

A

Measles

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4
Q

***What virus uses acetylcholine receptor

A

Rabies (think neurons)

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5
Q

What virus uses Sialic acid-containing oligosaccharides

A

Reovirus

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6
Q

What virus uses carcinoembryonic antigen gp family, aminopeptidase N, ACE 2

A

Coronavirus

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7
Q

What virus uses CD55, CAR, integrins alpha, beta

A

Coxsackie virus

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8
Q

What virus uses heparan sulfate; EGF receptor

A

CMV

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9
Q

What virus uses GLUT-1

A

HTLV

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10
Q

***What virus uses erythrocyte P antigen; and transferring receptor(canine)

A

parvovirus

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11
Q

Hodgkin’s lymphoma in children

A

EBV

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12
Q

Viruses whose genome can’t be used as mRNA

A

negative sense RNA viruses must transcribe into a positive sense using RNA polymerase

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13
Q

Positive sense RNA viruses transcribe to DNA and incorporate into host genome

A

retroviruses

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14
Q

RNA viruses replicate in cytoplasm except

A

influenza

retrovirus

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15
Q

RNA viruses are ssrNA except

A

reovirus

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16
Q

All DNA viruses can cause cancer except

A

parvo

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17
Q

100% nasopharyngeal carcinoma

A

EBV

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18
Q

HPV protein responsible for p53 tumor suppressor gene binding

A

E6

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19
Q

HPV subtypes associated with cervical cancer

A

HPV 16, 18

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20
Q

What HPV protein is responsible for the suppression of another protein responsible for tumor?

A

E2 suppresses E6 which suppresses P53 which suppresses tumor growth

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21
Q

Members of polyoma family:

A

(PAPOVA)
PApilloma v
POlyoma v
VAcuola v

22
Q

Causes hemorrhagic cystitis in BM transplant Px

A

BK (think Bad Kidney)

23
Q

HPV subtypes associated wtih oropharyngeal cancer

A

HPV 16

24
Q

Causes progressive multifocal leukoencephalopathy

A

JC (think Junky Cerebrum

25
Q

Theses viruses can induce tumors in mice and hamsters after injection. Affect kidneys or brain in humans.

A

JC and BK (Polyoma)

26
Q

Receptor for HHV-8

A

Integrin alpha3beta1

27
Q

HPV subtypes associated with laryngeal papilloma in children

A

HPV 6, 11

28
Q

Burkitt’s lymphoma

A

EBV

29
Q

All DNA viruses replicate in nucleus except

A

Poxvirus

30
Q

Virus associated with anogenital cancer

A

HPV

31
Q

Cervical intraepithelial neoplasia – what virus?

A

HPV

32
Q

Dysregulation of this gene leads to Burkitt’s

A

c-myc

33
Q

Causes Kaposi’s sarcoma

A

HHV-8

34
Q

Hepatitis viruses with hepatocellular carcinoma risk

A

HBV (oncogene)

HCV (from chronic inflammation)

35
Q

HBV is of this family?

A

DNA - Hepadnavirus

36
Q

HCV is of this family?

A

RNA - flavivirus

37
Q

HBV marker for immunity from infection

A

Anti-HBsAg

38
Q

HBV marker IgM anti-HB indicates

A

acute Hep B

39
Q

Marker for HBV that indicates immunity through vaccination

A

HBsAg

S antigen could also indicated acute/chronic hep b infection

40
Q

Serological tests revealed:
(+) HBsAg
(+) anti-HBeAg

A

Chronic HBV - high infectivity

positive s antigen
positive e antibody

41
Q

Serological tests revealed:
(+) HBsAg
(+) HBeAg

A

Acute HBV

positive s and e antigen

42
Q

Serological tests revealed:

(+) Anti-HBsAg only

A

immunization to HBV

43
Q

Serological tests revealed:
(+) Anti-HBsAg
(+) Anti-HBeAg
IgG Anti-HBcAb

A

HBV immunity from infection

44
Q

Serological tests revealed:

Antibody to HBcAg is IgM type

A

Acute HBV

IgG antibody indicates chronic HBV

45
Q

Adult T cell leukemia/lymphoma

A

HTLV-1

46
Q

Malignancies associated with HIV

A

Kaposi’s sarcoma
Non-Hodgkin’s B cell lymphoma
Rectum and tongue CA

47
Q

Avian retrovirus

A

alpha

48
Q

mouse retrovirus

A

beta

49
Q

gamma retrovirus

A

mammals

50
Q

delta retrovirus

A

Human T-lymphotropic virus

51
Q

fish retrovirus

A

epsilon

52
Q

lentivirus

A

HIV

3 Micro (9 decks)

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