RNA viruses I

Question 1

Major cause of laryngotracheobronchitis

Answer 1

PIV

Question 2

Koplik spots

Answer 2

Measles (rubeola)

Question 3

Influenzaviruses are all classified under

Answer 3

Orthomyxovirus

Question 4

Red spots on buccal mucosa and descending maculopapular rash (head to toe). Fever persists throughout. Cough and coryza.

Answer 4

Measles

Question 5

PIV subtype associated with bronchitis and pneumonia in infants and children

Answer 5

PIV 3

Question 6

High fever, headache, muscle pain, red/itchy eyes –> chest pain, shock, blindness and bleeding

Answer 6

Severe hemorrhagic fever caused by filovirus

ebola/marburg

Question 7

RNA virus with neuraminidase and hemagglutinin

Answer 7

Influenza A and B

Question 8

PIV subtype most commonly causing croup

Answer 8

PIV 1 & 2

Question 9

HDV requires this helper

Answer 9

HBV

Question 10

Clinical manifestations of influenza in youth and elderly differ how?

Answer 10

More toxic-looking.

Otitis media, more GI symptoms, febrile convulsions, croup

Question 11

Transmission of PIV

Answer 11

respiratory droplets or nasopharyngeal secretions

Question 12

RSV uses these glycoproteins

Answer 12

G –> attachment

F –> fusion

Question 13

RNA virus spread by mouse

Answer 13

Lymphocytic choriomeningitis virus (LCMV)

also lassa virus (both are arenaviruses)

Question 14

Bunyaviruses have ARTHROPOD vectors except for

Answer 14

Hantavirus

Question 15

Measles is highly contagious in this period

Answer 15

prodrome (pre-rash)

Question 16

Treatment for laryngotracheobronchitis

Answer 16

racemic epinephrine aerosol

Question 17

Most contagious period for mumps:

Answer 17

1-2 days before swelling

Question 18

Transmission of Hantavirus

Answer 18

Rats/rodents shed virus.

Humans inhale or have direct contact with particles. Or get bitten.

Question 19

Marburg and Ebola are both part of which family?

Answer 19

Filovirus

non-seg
enveloped

Question 20

Mumps symptoms:

Answer 20

Parotitis
Orchitis
Meningitis (aseptic)

Question 21

Fatal form of measles with confluent hemorrhagic skin eruptions

Answer 21

Black measles

Question 22

Negative-stranded RNA viruses:

Answer 22

ABOOFR = Always Bring Polymerase Or Fail Replication
(negative-sense viruses need polymerase to transcribe neg to positive strand)

Arena
Bunya
Paramyxo
Orthomyxo
Filo
Rhabdo

Question 23

Segmented viruses:

Answer 23

(all RNA viruses)
BOAR
Bunya
Orthomyxo
Arena
Reo

Question 24

Picornavirus subfamilies

Answer 24

PERCH
Polio
Echo
Rhino
Coxsackie
Hep A

Question 25

All picornaviruses are enteroviruses (feco-oral) except:

Answer 25

Rhinovirus

Question 26

Seal-like barking cough is called

Answer 26

Croup

Question 27

Hemorrhagic fever and biohazard agent.

Answer 27

Marburg | Ebola

Question 28

Biphasic illness: Prodrome with vague symptoms: fever, headahe, lower myalgia, cough Then abrupt cardiopulmonary phase (thrombocytopenia, hypoalbuminemia may be seen)

Answer 28

Hanta virus pulmonary virus

Question 29

Surface glycoprotein of influenza required for attachment of infecting virus to host-cell membrane

Answer 29

HA Hemagglutinin

Question 30

Surface glycoprotein of influenza required for release of virus from infected cells

Answer 30

NA Neuraminidase

Question 31

Horse, swine, birds are naturally infected by

Answer 31

Influenza A

Question 32

RNA virus that causes bronchiolitis and/or pneumonia commonly in children/babies

Answer 32

``` #1 RSV #2 Metapneumovirus ``` Both are Paramyxoviruses

Question 33

``` Symptoms: Anxiety Radicular pain Dysesthesia Dysautonomia Paralysis Hydrophobia ```

Answer 33

Rabies

Question 34

High fever with myalgia, eye symptoms, thrombocytopenia Hypotension Oliguria Convalescence

Answer 34

HFRS fever with bleeding (thrombocytopenia) and renal problems

Question 35

Rabies PostEP Category 1

Answer 35

Contact with infected animal Vaccine - no RIG - no

Question 36

Rabies PostEP Category 2

Answer 36

Superficial scratch Vaccine - yes RIG - no

Question 37

Rabies PostEP Category 3

Answer 37

Transdermal bite/scratch Vaccine - yes RIG - yes

Question 38

Hemorrhagic fever with renal syndrome / HFRS is caused by

Answer 38

Hanta virus

Question 39

Uncommon progressive CNS manifestation in a persistent measles infection

Answer 39

Subacute sclerosing panencephalitis

Question 40

Basis for antigenic shift or drift among influenza types

Answer 40

``` 3 HA types (H1, H2, H3) 2 NA (N1, N2) ```

Question 41

Implies minor change in antigen without change in subtype.

Answer 41

Antigenic drift

Question 42

Major change in either or both antigens AND change in subtype. Causes outbreaks and pandemics

Answer 42

Antigenic shift