Intro to Virology

Question 1

Complete and fully developed infectious viral particle composed of nucleic acid

Answer 1

Virion

Question 2

Envelopes covered in these contribute to the virus’s ability to

Answer 2

clump RBC

Question 3

Most efficient arrangement of subunits in a closed shell

Answer 3

Icosahedral

Question 4

List of DNA viruses (Mnemonic)

Answer 4

Herpes
Hepadna
Adeno
Papova
Parvo
Pox

Question 5

DNA viruses are all double-stranded, icosahedral and replicate in nucleus except for two. What are the exceptions?

Answer 5

Parvoviridae (ssDNA, remember “parv-“ means small)

Poxviridae (not icosahedral and replicates in cytoplasm)

Question 6

DNA and Enveloped

Answer 6

HHP
Herpes
Hepadna
Pox

Question 7

DNA and Naked

Answer 7

PAP
Papova
Adeno
Parvo

Question 8

Which RNA viruses are helical, but BULLET-shaped

Answer 8

Rhabdo

Question 9

Which RNA viruses are ICOSAHEDRAL

Answer 9

Reo, Picorna, Calici, Toga, Flavi

Question 10

Which RNA viruses are DOUBLE-STRANDED

Answer 10

Reo

Question 11

Which RNA viruses are NAKED

Answer 11

Reo, Picorna, Calici

Question 12

Which RNA viruses replicate in nucleus

Answer 12

Retro and Orthomyxo

Question 13

Nucleic acid + Capsid =

Answer 13

Nucleocapsid

Question 14

Period from viral attachment to first appearance of viral progeny

Answer 14

Eclipse period

Question 15

Viruses that reproduce without killing host cell

Answer 15

Temperate/lysogenic phage

Question 16

Capsids subunits

Answer 16

capsomere

Question 17

Viruses that kill their host cell

Answer 17

Virulent bacteriophage

Question 18

Protein that transfers disease without nucleic acids

Answer 18

Prion

Question 19

Which viruses are heat stable (morphology)?

Answer 19

icosahedral

Question 20

Which viruses are heat labile (component or structure)?

Answer 20

enveloped

Question 21

MgCl2 stabilizes

Answer 21

picorna and reo

Question 22

MgSO4 stabilizes

Answer 22

orthomyxo and paramyxo

Question 23

Na2SO4 stabilizes

Answer 23

herpes

Question 24

These viruses are acid resistant

Answer 24

enteroviruses (think stomach, GI)

Question 25

These viruses are destroyed in alkaline environment

Answer 25

ALL viruses

Question 26

Radiation inactivates these viruse

Answer 26

all

Question 27

Positive-sense RNA vs Negative-sense RNA

Answer 27

Positive-sense = 5’-3’, infectious, directly translated

Negative-sense = 3’-5’, non-infectious, requires conversion to positive-sense before translation

Question 28

Ether susceptibility

Answer 28

enveloped vs non-enveloped