Sleep-Wake Disorders Flashcards
What is the recommended hours on avg an adult should get?
7-9 hrs
What is the major consequence of acute or chronic sleep curtailment?
excessive sleepiness
Is excessive sleepiness obj or subj?
Subj, the pt reports the difficulty of staying awake
Define sleep deprivation
a discrepancy between hrs of sleep and hr required for optimal sleep fxning
What do the neurocognitive Sx of chronic sleep deprivation mimic?
psychiatric Sxs
What are you at risk for when you sleep less than 6 hrs or greater than 8 hrs/night?
- obesity
- diabetes
- HTN
- CVD
- stroke
- depression
- substance use
Which 2 hormones are affected when experiencing sleep deprivation?
ghrelin and leptin
What are the 2 distinct physiological states of sleep?
- NREM
2. REM
How many stages are in NREM?
3 stages
What is the term related to the time it takes to fall asleep?
sleep latency
Describe N1
brief transition between wakefulness and sleep; compromises between 2-5% of total sleep time
- Slow eye rolling movements are common
- lost awareness of the env but generally easily aroused
Describe N2
HR and RR decline
- 45-55% of total sleep
Describe N3
further reduction of HR, RR, BP, and response to external stimuli
- reduced sympathetic activity
What is another name for NE?
Delta sleep or slow wave
What type sleep do you receive from N3?
Restorative sleep
How is REM characterized?
- absence of skeletal muscle tone (muscle atonia)
- bursts of rapid eye movement
- myoclonic twitches of the facial and limb muscles
- reports of dreaming
- ANS variability
An avg adult experience NREM or REM 1st upon sleep?
NREM
Typically how many cycles occur over the 90-130 intervals across the sleep period?
4-6 cycles
What is sleep architecture?
the structural organization of NREM and REM sleep
Sleep fragmentation
disruption of sleep stages as indicated by excessive amounts of stage 1 sleep, multiple brief arousal, and frequent shifts in sleep staging
What are the 2 interactions that regulate sleep and wakefulness?
- sleep drive- sleep
2. circadian drive- wakefulness
Which 2 factors affect the circadian drives?
- exogenous
2. endogenous
Describe exogenous factors
various clues from the env (zeitebers) that help set our internal clock to a 24-hr cycle
What are the strongest external cue for wakefulness?
- light
What is the strongest external cue for sleep
darkness
What are the wakefulness neurotransmitters?
- dopamine
- NE
- SE
- Ach
- His
- Glu
- hypocretin
What are the sleep-promoting neurotransmitters?
- Adenosine
- GABA
- Glanin
How many hrs do short sleepers receive? Long sleepers?
Short sleepers: requiring less than 5 hrs/ night
Long sleepers: 10+ hrs/night