Depressive Disorders Flashcards
List some common Si/Sx of MDD
- Anhedonia
- insomnia,
- anergia
- feeling hopleless, helpless, or worthless
- flat affect
- negative though process
- Decrease in sexual libido
What are the key Sx of depression?
depressed mood and anhedonia
Which gender is most at risk, be specific w/ age group?
ratio is equal until adolescents where females are at a higher risk
What is a common reason older adults experience depression?
risk of depression increases as health deteriorate
T/F There is a single cause for depression
False, it is a multifaceted
What is the concordance rate for depression for identiacal twins?
50%
What are the 2 main neurotransmitters that affect depression?
- serotonin
2. NE
What is important to assess when you pt is depressed?
suicial ideation
Which factors increase the risk of suicide?
- hopelessness
- Substance Use
- Recent loss or separation
- History of suicide attempts
- Acute suicidal ideation
What are some ways the elderly experience depression differently?
- irritability
- cognitive changes
- longer recovery time
List some nursing Dx for depression
- Risk for suicide- highest priority
- Ineffective coping
- Hopeless
- Social Isolation
- Spiritual distress
- Self-care deficit
What is the MOA of SSRIs?
block the reuptake of serotonin in the synaptic cleft making serotonin more available
List some side effects of SSRIs
- seizures
- abnormal bleeding
- weight gain
- N/V
- tension headache
- Serotonin Syndrome
- Akathisia
Serotonin Syndrome
drug rxn that causes the body to have too much Serotonin that occurs when 2 drugs affect are taken simultaneously
List some Sx/Si of SE Syndrome
- Tachycardia
- Hypertensive
- Delirious
- Muscle Spasms
- diaphoresis
- pyrexia
- diarrhea
What are some contraindications for SSRIs?
Do not mix with
- Tramadol
- Triptans
- other SSRIs and SNRIs
List the SSRIs
- Celexa (citalopram)
- Lexapro (escitalopram)
- Prozac (fluoxetine)
- Luvox (Fluvoxamine)
- Paxil (paroxetine)
- Zoloft (sentraline)
What is the worst SSRIs? Explain why it is the worse
Paxil, the worse because it has horrible DC process
What is the MOA of SNRIs?
They block the reuptake of SE and NE
List the SNRIs
- Effexor (venlafaxine)
- Pristiq (Desvenlafaxine Succinate)
- Cymbalta (Duloxetine)
- Fetzim (levomilnacipran)
What are some side effects of SNRIs?
- N/V
- insomnia
- weight gain
- diaphoresis
- sexual dyfxn
What is the MOA of tricyclics?
inhibit the reuptake the NE and SE in the presynaptic cleft
List some side effects of TCAs
- anticholinergic effects ( urinary retention, blurred vision, dry mouth, tachycardia, constipation, esophageal reflux)
- orthostatic hypotension
- weight gain
- arrhythmias
When is the best time to administer a TCA? Why?
bed time because it has sedating effects