Sleep Disorders Flashcards

1
Q

when does non-REM sleep occur in the night

A

at the start of the night

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2
Q

physiological features of non-REM sleep

A

decreased cerebral blood flow

decreased HR + BP

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3
Q

what processes occur in non-REM sleep

A

protein synthesis
cell devision
growth

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4
Q

when does REM sleep occur

A

end of night

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5
Q

physiological features of REM sleep

A

increased cerebral blood flow

atonic muscles – decreased tone + strength

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6
Q

EEG activity in REM sleep

A

fast activity

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7
Q

EEG activity in non-REM sleep

A

synchronised, rhythmic activity

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8
Q

functions of REM sleep

A

consolidation of memory

maintains immune system

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9
Q

in what stage of sleep does dreaming occur

A

REM sleep

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10
Q

what things can suppress REM sleep

A

tricyclic antidepressants

alcohol

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11
Q

what are parasomnias

A

abnormal behaviour of the nervous system during sleep

can occur during non-REM and REM sleep

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12
Q

features of non-REM parasomnia

A

confusional arousals
sleep walking
sleep terrors / paralysis
bruxism (grining teeth)

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13
Q

REM sleep parasomnias are associated with what condition

A

Parkinsons

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14
Q

what is narcolepsy

A

chronic neurological disorder involving loss of the brains ability to regulate sleep-wake cycles

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15
Q

what are the 2 peak ages of onset of narcolepsy

A

age 15

age 36

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16
Q

symptoms of narcolepsy

A
daytime sleepiness 
cataplexy 
involuntary somnolence during eating/talking 
hyphagogic hallucinations 
sleep paralysis
17
Q

what is cataplexy

A

sudden loss of muscle tone due to strong emotions e.g. laughing / crying

18
Q

what are hyphagogic hallucinations

A

hallucinations that occur at the transition of wakefulness to sleep

19
Q

investigations for narcolepsy

A

overnight polysomnography

multiple sleep latency tests

20
Q

how are sleep latency tests carried out

A

4 x 25 minute naps are scheduled

– if they fall asleep within 10 mins and go into REM sleep this is diagnostic of narcolepsy

21
Q

what is the neurotransmitter that regulates sleep

A

hypocretin

will be low in narcolepsy

22
Q

drug treatments used in narcolepsy

A

modafinil
methylphenidate
clomipramine