SLE Flashcards
Which of the following is NOT a characteristic of vasculitis?
- Bleeding.
- Ischemia.
- Hyperglycemia.
- Immune response.
C
The primary vasculitis is classified into
Small - medium - large vessels vasculitis
Large vessels vasculitis like?
Takayasu’s arteritis - GCA - Cogan’s syndrome.
Medium vessels vasculitis
PAN - Buerger’s disease - Kawasaki disease - Primary angitis of CNS
Behcet disease is considered as ?
- Large vessel vasculitis.
- Medium.
- Small.
- Variable.
Variable
Wegener’s granulomatosis is also called
Granulomatous cholangitis
Drug induced vasculitis is considered?
- small vessels.
- Medium vessels.
- Large vessels.
Small vessels (ANCA positive)
Primarily affects the aorta and its major branches?
- GCA.
- Poly arteritis nedosa.
- Takayasu arteritis.
- Kawasaki’s disease.
C
Mostly involves the cranial branches of the aorta?
Giant cell arteritis
30 years old asian female presented to the ER with pain in her calfs started one week ago, associated with fever, night sweats and malaise. On examination, there was decreased pulsations at the brachial arteries and 15 mmHg difference in the systolic BP between the arms. There was also bruit over the subclavian arteries. What is the most likely diagnosis? And what is the next step?
- GCA.
- Takayasu arteritis.
- Polyarteritis nodosa.
- Wegener’s granulomatosis.
B. Next step is angiogram.
Which of the following treatments should be given for a patient with Takayasu arteritis?
- Methotrexate.
- Anti TNF.
- Prednisone.
- amoxycillin.
C
70 years old male presented to the ER with 2 weeks Hx of temporal pain and headache. ESR and CRP were elevated and biopsy showed necrotising arteritis of the temporal arteries, what is the most likely diagnosis?
GCA
Which radiological studies is the best to diagnose GCA?
- US.
- CT.
- X ray.
- MRI.
US (halo sign)
Takayasu arteritis is best diagnosed by?
- CT angio.
- X ray.
- MRI.
- US.
CT angio
The steroid therapy for a patient with temporal arteritis should be maintained for up to ?
- 6 months.
- 1 year.
- 2 to 3 years.
- 5 years.
2 to 3 years
What is a must if temporal arteritis is suspected?
Start prednisone (1mg/ Kg) for at least 4 weeks and order a temporal artery biopsy.
40 to 50% of patients with temporal arteritis has a coexisting?
polymyalgia rheumatica
Characterized by hip and shoulder muscle pain and morning stiffness in addition to synovitis. BUT, RF and ACP are negative.
Polymyalgia rheumatica
Affects the small and medium sized muscular arteries
Polyarteritis nodosa
Associated with HBV
PAN
Has mesenteric involvement and testicular pain or tenderness
PAN
PMN invasion of all layers of the blood vessels leading to reduced luminal diameter, ischemia, infarction and aneurysms.
PAN
Elevated ESR and P- ANCA are evident
PAN
Characterized by oral mucous membrane changes, erythema and edema of the extremities.
Kawasaki disease
Characterized by asthma and eosinophilia + positive P- ANCA
Churg strauss syndrome
Characterized by sinusitis, oral ulcers + chest infiltrates and high RFT (hematuria)
Granulomatosis with polyangiitis
Positive C- ANCA is present in 90% of patients with?
- PAN.
- Kawasaki disease.
- GCA.
- Wegener granulomatosis (granulomatosis with polyangiitis)
D
Sinus disease + pulmonary disease + glumorulonephritis =
Granulomatosis with polyangiitis (wegener)
How can we distinguish between PAN and Wegener?
In PAN there is NO pulmonary involvement
