PUD / GERD Flashcards
Parietal Cells receptors
Acetylcholine + Gastrin + Histamine
CLF and CRF have increased risk of PUD due to
Increased gastrin levels and decreased defense mechanisms
Acute ulcers seen in patients with severe burns
Curling’s ulcers
Has antibiotic effect against H. Pylori
Bismuth
The gold standard test for diagnosing GERD
Ambulatory esophageal pH monitoring
The optimal technique for determining the presence and severity of esophagitis
Endoscopy
The only reliable test for detecting Barrett’s esophagus
Endoscopy
Superficial + not extending to the muscularis
Erosion
Necrotic + involving the muscularis
Acute ulcer
Necrotic + through the deep layer
Chronic ulcer
PUD most commonly affect ……. part of the stomach.
The anterior and posterior antrum
More common in patients with blood group O
Duodenal ulcer
Associated with increased serum pepsinogen
Duodenal ulcer
Common in middle aged
D. Ulcers
Common in late aged
Gastric ulcer
Associated with blood group A
G. Ulcer
Impaired antral motility is associated with
G. Ulcer
Produce large amount of urease, breaking down the urea to alkaline ammonia and CO2.
H. Pylori
Zollinger Ellison cancer is more common in
G. Ulcers
The confirmatory test for PUD
Endoscopy
Radiological modality used for PUD
Barium meal study
Sucralfate is
A coating drug for PUD
Forms a complex with mucus
Bismuth
The only FDA approved prostaglandin analogue
Mesoprostol
Inhibits BAO and MAO and causes blurred vision and urinary retention as side effects
Anticholinergics
Cimetidine, Ranitidine … are
H2 antagonists
Decreases gastric acid secretion by inhibition of H K ATPase proton pump
PPI (omeprazole - Esomeprazole …)
Best combination of drugs for PUD
PPI + Amoxicillin + Clarithromycin
< 5 mm erosion of one fold
Grade A
> 5mm
Grade B
Several folds + <75%
Grade C
Several folds + >75%
Grade D
The most prevalent LA grade of esophagitis
Grade B
The optimal technique for detecting the presence and the severity of esophagitis
Endoscopy
Inhibits transient LES relaxation post prandial
Baclofen
Small flexible band used to treat GERD
Linx system
