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Medicine > Leukemia > Flashcards

Leukemia Flashcards

1
Q

EBV causes

A

Burrkett’s leukemia/lymphoma

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2
Q

HTLV1 causes

A

Adult T cell leukemia

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3
Q

Pulmonary leukostasis is more common in

A

AML

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4
Q

Coagulopathy is common in which AML?

A

AML M5 + AML M3

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5
Q

RES infiltration is common in

A

ALL

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6
Q

Gum hypertrophy is common in

A

AML M5

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7
Q

Sweet’s syndrome and chloroma

A

AML

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8
Q
  • 15 to 20 micro m.
  • fine chromatin.
  • predominant nucleoli 1-4.
  • moderate basophilic cytoplasm.
  • Auer rods may present.
A

Myeloblast

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9
Q
  • 10 to 15 micro m.
  • condensed chromatin.
  • scanty cytoplasm.
  • inconspicuous nucleoli 1-2.
  • auer rods are absent.
A

Lymphoblast

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10
Q

Neutrophil primary granules are stained in?

A

Myeloperoxidase (MPO) (myeloblasts strong +ve, monoblasts faint +ve)

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11
Q

Phospholipids are stained in?

A

Sudan black B (SBB)

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12
Q

Cellular enzymes are stained in ?

A

Specific esterase (myeloblasts strong +ve)

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13
Q

M2 , M3 ,M4eo

A

Favorable prognosis

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14
Q

M0, M1, M5, M6, M7

A

Unfavorable prognosis

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15
Q

t(8,21), t(15,17), inv(16), normal CG

A

Favorable prognosis

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16
Q

t(9,22), -5, -7, +8. Complex CG

A

Unfavorable prognosis

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17
Q

Adverse prognostic factors in ALL: ( high risk)

A

t(9,22).
t(4,11).
trisomy 8.
Hypodiploidy

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18
Q

Postremission therapy aimed at destroying clinically occult disease.

A

Remission consolidation (intensification) therapy

19
Q

Low dose of chemotherapy aimed at preventing the reemergence of leukemia.

A

Maintenance (continuation) therapy

20
Q

Initial chemotherapy treatment aimed at achieving a complete remission.

A

Remission induction therapy

21
Q

Complete remission of leukemia

A

■ Disappearance of leukemia after treatment with full regeneration of normal hematopoiesis.

■ <5% blasts in a normocellular bone marrow.

■ Return of peripheral blood count to normal:

■ Neutrophils count > 1500/µL. ■ Platelets count >100,000/µL. ■ hemoglobin level >10 gm/dL.

■ Disappearance of sings and symptoms.

22
Q

Persistent leukemia, not detectable by light microscopy.

A

Minimal residual disease

23
Q

Leukemia that does not enter CR.

A

Refractory Leukemia

24
Q

WBC> 100 000

A

AML

25
Q

WBC> 200 000

A

ALL

26
Q

Cytoreduction Tx for AML

A

Hydroxyurea

27
Q

Cytoreduction Tx for ALL

A

Steroids

28
Q

Allopurinol + Rasburicase

A

Used to treat Tumor Lysis Syndrome

29
Q

FFP + cryoprecipitate are used to treat

A

DIC coagulopathy In Leukemic patients

30
Q

Acute leukemia associated with CNS disease at presentation?

A

ALL

31
Q

Aim is to reconstitute normal hematopoiesis and to prevent GVL effect.

A

Allogeneic SCT

32
Q

high-dose ara-C is used in?

A

Remission consolidation therapy (post remission)

33
Q

ATRA (all trans retinoic acid) is used to treat?

A

AML M3

34
Q

Used to treat AML M3, and can result in differentiation syndrome?

A

ATRA (all trans retinoic acid)

35
Q

Which of the following is NOT done to manage differentiation syndrome resulted from ATRA Tx?

  • Hold ATRA.
  • Stop ATRA.
  • Give dexamethasone.
  • Give diuretics.
A

Stop ATRA

36
Q

Induces apoptosis in the leukemic cells

A 
Arsenic trioxide (ATO) 
*induces cardiotoxicity + neurotoxicity
37
Q

Hyper CVAD drugs used to treat

A

ALL

38
Q

For relapsed or patients with high risk to develop leukemia

A

Allogeneic SCT

39
Q

Leukemia mainly seen in children

A

ALL

40
Q

Leukemia mainly seen in elderly

A

CLL

41
Q

The most common malignancy in childhood?

A

ALL

42
Q

Which of the following is specific manifestation of AML?

  • Gumhypertrophy.
  • violaceous skin deposits.
  • Testicular enlargement.
  • mediastinal mass (SVCO).
A

A and B

43
Q
  • Testicular enlargement.

- mediastinal mass (SVCO). Both are specific for?

A

ALL

44
Q

DIC is specific for which leukemia?

A

AML

Medicine (19 decks)

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