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PATHOLOGY > Skin Disorders > Flashcards

Skin Disorders Flashcards

1
Q
A
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2
Q

Skin’s 4 main functions

A

protection, sensation, thermoregulation, metabolic function

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3
Q

Skin and subcutaneous tissue provides a major source for vitamin ___

A

Vitamin D

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4
Q

Primary Lesion - Macule

A

Flat lesions observed due to change in color.

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5
Q

Primary Lesion - Patch

A

Flat lesions > 1 centimeter

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6
Q

Primary Lesion - Papule

A

Lesions raised above the skin; increase in consistency.;

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7
Q

Primary Lesion - Plaque

A

Raised lesion > 1 cm

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8
Q

Primary Lesion - Nodule

A

Raised dome shaped lesion > 1.0 cm

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9
Q

Primary Lesion - Tumor

A

Large lesion, greater than nodule

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10
Q

Primary Lesion - Wheal

A

Increased fluid in tissue (edema/swollen); blanchable

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11
Q

Primary Lesion - Vesicle

A

Sharply marginated elevated lesion with fluid-filled lesion,

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12
Q

Primary Lesion - Bullae

A

Sharply marginated elevated lesion with fluid-filled lesion, > 1 cm

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13
Q

Primary Lesion - Pustule

A

Focal epidermal accumulation of inflammatory cells, serum, sometimes microorganisms; discolored (i.e., yellow/green) entrapped fluid pocket within epidermis

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14
Q

Freckles, drug rash, birthmark, vitiligo, malignant melanomas, these are examples of

A

Macules

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15
Q

Neurofibroma, breast carcinoma, keratoacanthoma are examples of

A

Tumors

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16
Q

Hives, dermatographism are examples of

A

Wheals

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17
Q

Bullous pemphigoid; Pemphigus are examples of

A

Bullae

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18
Q

Pustular psoriasis, impetigo are examples of

A

Pustules

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19
Q

Secondary Lesion - Crust

A

Oozing from vesicles or drying up of vesicles

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20
Q

Secondary Lesion - Scale

A

Excess of surface keratin material

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21
Q

Secondary Lesion - Fissure

A

Linear Break in epidermis

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22
Q

Secondary Lesion - Erosion

A

Shallow scooped out break in epidermis

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23
Q

Secondary Lesion - Ulcer

A

Complete removal of epidermis with discrete margins, and may extend into dermis and /or fat

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24
Q

Secondary Lesion - Scar

A

Repair of skin with fibrous tissue

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25
Q

Secondary Lesion - Atrophy

A

Loss of tissue with little or no replacement

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26
Q

Examples of Scars

A

Acne ice-pick scar, Hypertrophy, Keloid

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27
Q

Examples of Scales

A

Psoriasis, ichthyoses, desquamation

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28
Q

Examples of Atrophy

A

Striae

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29
Q

Special Lesions - Alopecia

A

Loss of hair

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30
Q

Special Lesions - Comedo

A

Involves a hair follicle and the duct or opening of the sebaceous gland

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31
Q

Special Lesions - Sebaceous cyst

A

Large encapsulated cavity filled with sebaceous material

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32
Q

Special Lesions - Folliculitis

A

Superficial pustules or inflammation in hair follicles only

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33
Q

Special Lesions - Furuncle

A

Deeper larger infection of hair follicle

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34
Q

Special Lesions - Abscess

A

Cavity filled with pus

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35
Q

Special Lesions - Telangiectasia

A

Dilatation of small blood vessels that are permanently enlarged

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36
Q

Special Lesions - Ecchymoses

A

Large area of bleeding into skin

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37
Q

Special Lesions - Lichenification

A

Thickening of the skin

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38
Q

Epidermis consists of a 4-layered keratinized squamous epithelium, the layers are:

A

• Stratum corneum • Stratum granulosum • Stratum spinulosa • Basal cell layer

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39
Q

Dermis

A

fibroelastic vascularized tissue

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40
Q

Subcutaneous tissue (hypodermis)

A

contains various amounts of adipose tissue dependent on location, gender, etc.

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41
Q

Epidermal appendages are developed from

A

developed embryologically from the downward growth of epidermal epithelium

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42
Q

Epidermal appendages include

A

• Hair follicles • Sweat glands • Sebaceous glands • Nails

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43
Q

Atypical lymphocytic epidermotropism on biopsy indicates

A

Mycosis Fungoides (MF) or Cutaneous T cell Lymphoma (CTCL)

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44
Q

Red, scaly lesions that worsen in dry, cold climate

A

seborrheic dermatitis

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45
Q

Child w/ food allergies and asthma + rash would likely indicate

A

atopic dermatitis

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46
Q

Oil spots and nail pitting are associated with

A

Psoriasis

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47
Q

+ Auspitz =

A

Psoriasis

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48
Q

Histology shows munro micro abscesses

A

Psoriasis

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49
Q

Histology shows Pautrier’s microabscess

A

Mycosis Fungoides (MF) or Cutaneous T cell Lymphoma (CTCL)

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50
Q

pruritic psoriaform rash on buttocks, non-responsive to steroids

A

Mycosis Fungoides (MF) or Cutaneous T cell Lymphoma (CTCL)

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51
Q

Pruritic lesions + gluten sensitivity

A

Dermatitis Herpetiformis

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52
Q

IF shows IgA deposition w/in dermal papillae

A

Dermatitis Herpetiformis

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53
Q

Child nose/mouth vesicular lesions + previous Strep or Staph infection

A

Bullous impetigo

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54
Q

“Honey-crusted” lesions

A

Bullous impetigo

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55
Q

Oral ulcers and flaccid blisters that easily rupture

A

Pemphigus (Vulgaris Variant)

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56
Q

IgG and C3 around each keratinocyte (fish net appearance)

A

Pemphigus (Vulgaris Variant)

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57
Q

“Nikolsky Sign”

A

Pemphigus (Vulgaris Variant)

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58
Q

Histology: bullae just above the basal cell layer (suprabasal).

A

Pemphigus (Vulgaris Variant)

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59
Q

Tense bullae on flexor aspects, primarily of legs

A

Bullous Pemphigoid

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60
Q

Subepidermal bullae (clefting b/w D-E) associated with eosinophils

A

Bullous Pemphigoid

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61
Q

IF shows Linear deposits of IgG along basement membrane

A

Bullous Pemphigoid

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62
Q

IF shows a granular band of Ig and complement along the D-E junction

A

Chronic Discoid Lupus Erythematosus (CDLE)

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63
Q

pruritic polygonal, purple papules on wrist

A

Lichen Planus

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64
Q

Band like lymphocyte infiltrate at D-E junction with basal cell degeneration

A

Lichen Planus

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65
Q

(scattered “Colloid or Civatte bodies”): wedge shaped thickening of granular cell layer

A

Lichen Planus

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66
Q

“saw toothing”

A

Lichen Planus

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67
Q

fibrotic thickening of fat septa, giant cells

A

Erythema nodosum

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68
Q

Painful tender nodules on lower legs

A

Erythema nodosum

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69
Q

Pearly papule on nose

A

Basal Cell Carcinoma (BCC)

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70
Q

Most common skin malignancy

A

Basal Cell Carcinoma (BCC)

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71
Q

Lymphoplasmacytic infiltrate at periphery

A

Medullary Carcinoma

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72
Q

High grade features with low-grade behavior

A

Medullary Carcinoma

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73
Q

Blue Dome Cysts

A

Pure Fibrocystic Change w/ no increased risk for breast cancer

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74
Q

Mucin lakes with malignant cell islands

A

Colloid Carcinoma

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75
Q

nests of uniform tumor cells suspended in mucin lakes

A

Colloid Carcinoma

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76
Q

Seborrheic Keratosis Clinical Presentation

A

middle age, elderly - face & trunk “stuck-on” raised pigmented papule

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77
Q

Seborrheic Keratosis Histological Presentation

A

horn cyst formation, sharply demarcated

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78
Q

Dermatosis Papulosa Nigra

A

smaller Seborrheic Keratoses on face of black ppl

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79
Q

Lesser-tralet sign

A

sudden onset of many papules due to paraneoplastic syndrome (Hormone excreting tumor)

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80
Q

Seborrheic Keratosis is from

A

keratinocytes

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81
Q

Ancanthosis Nigricans Clinical Presentation

A

Thick, hyperpigmented velvety skin in flexural areas ie. axilla, groin, neck, anogenital

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82
Q

Ancanthosis Nigricans Histological Presentation

A

papillated hyperkeratosis, rete ridges

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83
Q

Ancanthosis Nigricans typically seen in

A

Obese, Endocrine Disorders (diabetics)

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84
Q

Fibroepithelial polyp Clinical Presentation

A

soft, flesh colored “skin tag”/acrochordon on neck, trunk, face, intertriginous/skin folds

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85
Q

Fibroepithelial polyp Histological Presentation

A

slender, fibrovascular stalk

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86
Q

Keratoacanthoma Clinical Presentation

A

flesh colored dome-like nodule w. central keratin-filled crater , on face, hand in sun-exposed Caucasians > 50

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87
Q

Keratoacanthoma Histological Presentation

A

cup-shaped epithel prolif w. central keratin plug, may have atypical keratinocytes

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88
Q

Keratoacanthoma possibly is due to

A

HPV

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89
Q

Keratoacanthoma treatment

A

r/o SCC, self-limited

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90
Q

Epithelial Inclusion Cyst/Epidermoid cyst Clinical Presentation

A

firm dermal or subcutaneous nodule with down-growth and cystic expansion of epidermis

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91
Q

Epithelial Inclusion Cyst/Epidermoid cyst Histological Presentation

A

well circumscribed

92
Q

Milium

A

small Epithelial Inclusion Cyst

93
Q

Tricholemmal cyst

A

Hair follicular epithelium-derived on scalp

94
Q

Trichilemomma Clinical Presentation

A

flesh colored papules, on central face, perioral areas from hair follicle origin

95
Q

Cowden’s Disease

A

Trichilemomma may be internal marker for malignancy assoc w. breast CA and thyroid CA

96
Q

Cylindroma Clinical Presentation

A

single or multiple coalescing nodules on forehead & scalp sweat gland origin

97
Q

turban tumor

A

multiple coalescing cylindromas on forehead & scalp

98
Q

Cylindroma Histological Presentation

A

“jig-saw puzzle” islands of basaloid cells in dermis

99
Q

Syringoma Clinical Presentation

A

Multiple small tan papules Near lower eyelid; women - sweat gland origin

100
Q

Syringoma Histological Presentation

A

“Tadpole” shaped islands of basaloid

101
Q

Syringoma can mimic

A

Microcystic Adnexal Carcinoma

102
Q

Muir Torre Syndrome (HNPCC)

A

Sebaceous Adenoma: Microsatellite Instability - a variant of Lynch Syndrome!!!!

103
Q

Sebaceous Adenoma

A

May be associated with Muir Torre syndrome; microsatellite instability

104
Q

Actinic Keratosis Clinical Presentation

A

Premalignant, dysplastic lesion Typically

105
Q

Actinic Keratosis Histological Presentation

A

atypia in lower epidermis, basal cell hyperplasia & dyskeratosis, damaged collagen ->blue-grey elastic fibers

106
Q

Actinic Keratosis is seen commonly in

A

elderly, light-skinned, sun-exposed

107
Q

SCC Clinical Presentation

A

non-healing ulcerated nodule in sun-exposed ind, xeroderma pigmentosum, etc

108
Q

SCC may show what orally?

A

white thickened plaques on mucosa (leukoplakia)

109
Q

SCC Histological Presentation

A

In situ SCC has full thickness epidermal atypia; Invasive SCC breaks thru D-E junction into underlying dermis (more advanced)

110
Q

Bowen’s Disease

A

demarcated red scaling plaques = In situ SCC

111
Q

BCC Clinical Presentation

A

pearly papules, surrounded by telangectasias, due to sun exposure

112
Q

BCC Histological Presentation

A

basal cell prolix into dermis + “peripheral palisading” (basaloid islands; NOT cylindroma or syringoma)

113
Q

most common type of skin CA malignancy?

A

BCC

114
Q

Nevoid Basal Cell Syndrome/Gorlin syndrome

A

rare, AD, many BCCs throughout life

115
Q

BCC is associated w/ what gene

A

activated SHH - loss of PTCH + p53 gene function

116
Q

Lentigo Clinical Presentation

A

hyperpigmented macules 5-10mm on skin & MM, do not darken in sun, common from infancy

117
Q

Cutaneous Horns may be present in

A

Actinic Keratosis –> SCC

118
Q

Lower Lip skin nodule/ulcer think

A

SCC

119
Q

Upper Lip skin nodule/ulcer think

A

BCC

120
Q

Lentigo Histological Presentation

A

“lentiginous growth” or hyper pigmented, linear hyperplasia of melanocytes (elongated, thin rete ridges)

121
Q

Lentigo vs Freckle

A

Lentigo do not darken in sun, larger, darker, skin or mucous membrane

122
Q

Melanocytic Nevus - 6 types

A

Common, may present in childhood or adulthood: Junctional, Compound, Intradermal, Blue, Halo, Dysplastic

123
Q

Middle aged + pimple on nose that won’t go away; you should think =

A

BCC

124
Q

Junctional Nevus Clinical Presentation

A

flat, smooth, uniformly pigmented (brown to black)

125
Q

Junctional Nevus Histological Presentation

A

symmetric nest of melanocytes at DE junction (young)

126
Q

Compound Nevus Clinical Presentation

A

raised, smooth border, uniform pigment

127
Q

Compound Nevus Histological Presentation

A

nests of melanocytes in BOTH D & DE junction (aging nevus proceeds from junction into D)

128
Q

Intradermal Nevus Clinical Presentation

A

raised, smooth border, uniform pigment (or flesh-colored)

129
Q

Intradermal Nevus Histological Presentation

A

nests of melanocytes in dermis entirely (not at DE Jct)

130
Q

Blue Nevus Clinical Presentation

A

small, blue-black nodules

131
Q

Blue Nevus Histological Presentation

A

heavily pigmented dendritic melanocytes

132
Q

Halo Nevus Clinical Presentation

A

white zone around mole

133
Q

Halo Nevus Clinical Presentation

A

lymphocytic infiltrates surrounding compound or intradermal melanocytes

134
Q

Dysplastic Nevus (BK or Clarks mole) Clinical Presentation

A

irregular borders/pigment, sun exposed or non-exposed

135
Q

Dysplastic Nevus Syndrome or Familial Melanoma Syndrome

A

Numerous dysplastic nevi (genetic)

136
Q

Dysplastic nevus presence increases risk for

A

Melanoma

137
Q

Dysplastic Nevus (BK or Clarks mole) Histological Presentation

A

Cytologic and architectural atypia → Shows features of pre-melanoma

138
Q

Dysplastic Nevus gene involvement

A

p161NK4A, BRAF, CDK4

139
Q

Which malignancy has the highest increase in incidence?

A

Malignant melanoma - 90% increase over 30yrs

140
Q

Most common malignancy in young adults?

A

Malignant melanoma

141
Q

Malignant melanoma risk factors:

A

FHx, red/blonde hair, freckling, 3+ blistering sunburns, 3+ outdoor jobs, presence of actinic keratosis, dysplastic nevi syndrome, tanning-UVA

142
Q

1-2 risk factors for Malignant melanoma increases your risk by

A

3.5X

143
Q

3+ risk factors for Malignant melanoma increases your risk by

A

20X

144
Q

ABCDE of Malignant Melanoma

A

Asymmetric shape, Border irregularity, Color - nonuniform, Diameter >5mm, Elevated

145
Q

Melanoma can be found on whack body parts

A

skin, oral, conjunctiva, orbit, nail bed, esophagus

146
Q

Melanoma prognosis is dependent on

A

Depth of invasion and clinical stage

147
Q

Types of Melanoma

A

Superficial spreading melanoma Nodular melanoma: (vertical growth) Lentigo maligna melanoma (Hutchinson’s freckle): early phase radial growth Acral lentiginous melanoma: adial growth

148
Q

Breslow Depth measures

A

Depth of invasion of melanoma below the stratum granulosum

149
Q

Melanoma Histological Presentation

A

atypical melanocytes w. nuclear hyperchromasia, mitosis, prominent nucleoli, individual necrosis, lack maturation amelanotic = melanin absent from cells

150
Q

Clarks Level I - Melanoma

A

(In situ) Intra-epidermal - 100% survival rate of 5 years

151
Q

Clarks Level II - Melanoma

A

Invades papillary dermis - 90% survival rate of 5 years

152
Q

Clarks Level III - Melanoma

A

Fills papillary dermis - 70% survival rate of 5 years

153
Q

Clarks Level IV - Melanoma

A

Invades reticular dermis - 40% survival rate of 5 years

154
Q

Clarks Level V - Melanoma

A

invades SubC fat - 25% survival rate of 5 years

155
Q

Clinical Stage of Melanoma

A

Lymph node involvement, distant metastases - 5 year survival

156
Q

Benign Fibrous Histiocytoma (Dermatofibroma) Clinical Presentation

A

Typically on legs of adults (trauma), tan-brown, firm papule “dimple in center” w/ lateral compression

157
Q

Benign Fibrous Histiocytoma (Dermatofibroma) Histological Presentation

A

non encapsulated prolif of spindle shaped fibroblasts

158
Q

Dermatofibrosarcoma protoberans DFSP Clinical Presentation

A

On trunk - firm, indurated solid nodules; may ulcerate

159
Q

Dermatofibrosarcoma protoberans DFSP Histological Presentation

A

slow growing fibrosarcoma, locally aggressive, rare metastasis; radially oriented (storiform pattern) fibroblasts, mitosis

160
Q

Dermatofibrosarcoma protoberans DFSP gene involvement

A

translocation of COLIAI and PDGFb

161
Q

Mastocytosis Clinical Presentation

A

pruritus, flushing, rinorrhea, dermal edema & erythema (wheal), dermatographism

162
Q

Mastocytosis Histological Presentation

A

high # mast cells, purple cytoplasmic granules

163
Q

Darier’s Sign indicates

A

Mastocytosis or Urticaria Pigmentosum

164
Q

Urticaria Pigmentosum Clinical Presentation

A

Mastocytosis that is localized to the skin with round to oval red-brown papules and plaques

165
Q

Urticaria Pigmentosum Histological Presentation

A

high # mast cells, eosinophils, edema (metachromatic stain: giemsa, toludine)

166
Q

Mycosis Fungoides or Cutaneous T cell Lymphoma Clinical Presentation

A

> 40y/o, scaling patch (like psoriasis), indurated plaque, re-brown nodule, disseminated

167
Q

Mycosis Fungoides or Cutaneous T cell Lymphoma Histological Presentation

A

Pautrier’s microabscess, bandlike atypical lymphocyte infiltration in dermia, mycosis cells w/ cerebriform-like nuclei

168
Q

Patch stage of Mycosis Fungoides Histological Presentation

A

lymphocytic epidermatropism

169
Q

Tumor stage of Mycosis Fungoides Histological Presentation

A

Pautrier’s microabscess (cluster of infiltrative atypical CD4+ lymphocytes in epidermis), mycosis cells with cerebriform nuclei

170
Q

Sezary Syndrome

A

systemic mycois fungoides - white scaly hands/palms

171
Q

Urticaria Clinical Presentation

A

Hives, wheals: Type I Hypersensitive (IgE) response to an Ag + histamine (mast cells)

172
Q

Urticaria Histological Presentation

A

dermal edema, sparse dermal inflammation

173
Q

Eczema Clinical Presentation

A

Allergic Contact Dermatitis, Atopic Dermatitis, Seborrheic Dermatitis

174
Q

Eczema Histological Presentation

A

intraepidermal vesicles; dermal edema w. possible eosinophils/lymphocytes; w/ overlying parakeratosis

175
Q

Allergic Contact Dermatitis

A

Type IV HSN - poison ivy, jewelry, etc

176
Q

Atopic Dermatitis Clinical Presentation

A

Type I HSN; Infant/Child w/ +FHx of eczema, asthma, allergies w/ pruritic rash, erythema, excoriation, lichenfiation of skin (FLEXURAL areas, not nasolabial)

177
Q

Seborrheic Dermatitis Clinical Presentation

A

NASOLABIAL FOLDS, ears, eyebrows, scalp (oil distribution); red, scaly, itchy, dry flakes; ‘comes and goes’; SEASONAL

178
Q

Erythema Multiforme Clinical Presentation

A

bull’s eye target lesion; limited hypersensitivity to drugs (sulfamide, dilantin, barbituate, penicillin)

179
Q

Erythema Multiforme Complications

A

EM Major/SJS: mucous membrane involvement TEN: epithelial necrosis and sloughing

180
Q

Erythema Nodosum Clinical Presentation

A

15-30y/o lower legs/shins, red painful nodules

181
Q

Erythema Multiforme etiology

A

HSV, mycoplasma, idiopathic

182
Q

Erythema Multiforme drugs

A

sulfamide, dilantin, barbituate, penicillin

183
Q

Erythema Nodosum Histological Presentation

A

fibrosis thickening of fat septa, giant cells

184
Q

Erythema Nodosum etiology

A

beta hemolytic strep, herpes, fungal; BCP, sulfonamides; UC, sarcoidosis, Behcet’s syndrome

185
Q

Erythema Induratum clinical presentation

A

adolescents & menopausal women, back of legs

186
Q

Erythema Induratum Histological Presentation

A

granulomatous inflam of fat lobules & necrosis

187
Q

Psoriasis Clinical Presentation

A

salmon-colored papules + silver scales on EXTENSOR surfaces; Usually assoc w/ RA, AIDS, etc

188
Q

Koebner’s phenomenon

A

psoriasis lesions develop at site of trauma

189
Q

Auspitz sign

A

psoriasis removal of scale induces miniscule blood droplets from dilated vessels in dermal papillae

190
Q

Psoriasis nails

A

oil spot, pitting, onycholysis

191
Q

Psoriasis Histological Presentation

A

Munro Microabscesses: neutrophils w/in the epidermis, Periodic thinning of epidermis where it overlies dermal papillae + acanthosis + parakeratotic hyperkeratotsis w/ nuclei retained in corneum

192
Q

Von Zumbush Syndrome

A

acute onset pustular psoriasis with fever & arthritis = life threatening

193
Q

Lichen Planus Clinical Presentation

A

polygonal purple papules, pruritic, may coalesce into plaques, highlighted by white lines (Wickham striae) found on wrist, shin, scalp alopecia, lumbar, buccal mucosa; drug-induced possibly

194
Q

Lichen Planus Histological Presentation

A

Colloid/Civatte bodies (basal cell degeneration), saw-tooth rete + acanthosis

195
Q

Lupus Erythematosus Clinical Presentation

A

AID of CT; worsens in sun, macular butterfly rash with acute SLE

196
Q

Chronic Discoid LE Clinical Presentation

A

sharp margins, scaly, atrophic red plaques on sun-exposed areas (anti-DNA, RF) – basal cell degeneration (vacuolization): epidermal atrophy with keratin plugging

197
Q

Chronic Discoid LE Histological Presentation

A

Lymphocytic infiltrates along D-E junction,

198
Q

IF for Chronic Discoid LE

A

granular band of Ig along D-E Jct “Lupus Band”

199
Q

Acne Vulgaris Clinical Presentation

A

Adolescents, comedones (w- and b-heads), acne

200
Q

Rosacea Clinical Presentation

A

middle-ages women, flushing -> red/telangiesctasia -> pustules -> rhiniophyma

201
Q

Bullous Impetigo Clinical Presentation

A

“honey crust” subcorneal blister, on face, hands, trunk due to Staph or Strep; typically in children/infants

202
Q

Bullous Impetigo Histological Presentation

A

subcorneal pustules with neutrophils & gram pos agents

203
Q

Pemphigus (Vulgaris variant) Clinical Presentation

A

flaccid vesicles & bullae (rupture easily; oral mucosa, scalp, trunk; AI disorder of desmosomes protein; 40-60y/o

204
Q

Nikolsky Sign

A

pressure on flaccid bullae –> lateral extension of blister = Pemphigus (Vulgaris variant)

205
Q

Pemphigus (Vulgaris variant) Histological Presentation

A

Tombstone row of basal cells - suprabasilar, thin bulllae covering

206
Q

IF for Pemphigus (Vulgaris variant)

A

Fish-net, IgG around every keratinocyte

207
Q

Bullous Pemphigoid Clinical Presentation

A

Tense bulla, do not rupture easy, skin, mucosa, lower legs; AI disorder of hemidesmosomes (lamina lucida); elderly

208
Q

Bullous Pemphigoid Histological Presentation

A

subepidermal bulla, + eosinophils, few lymphocytes & neutrophils

209
Q

IF for Bullous Pemphigoid

A

linear deposits IgG along BM

210
Q

Dermatitis Herpetiformis Clinical Presentation

A

Recurrent pruritic, tiny, grouped vesicles; Associated w/ Celiac; IgA to gluten Xreacts w/ fibrils of BM

211
Q

Dermatitis Herpetiformis Histological Presentation

A

tips of dermal papillae filled w. neutrophils (microabscesses)

212
Q

IF for Dermatitis Herpetiformis

A

granular IgA deposits at dermal papillae tips

213
Q

Verruca Clinical Presentation

A

benign epithelial hyperplasia due to HPV

214
Q

Verruca Types

A

vulgaris (most common, anywhere esp hands); plana (flat); plantaris; palmaris; acuminatum (cauliflower-like venereal wart on genitalia/perianal/rectal)

215
Q

Verruca Histological Presentation

A

papillated epidermis, koilocytotic (viral) changes = irregular nuclei surrounded by cytoplasmic halo

216
Q

Molluscum Contagiosum Clinical Presentation

A

discrete, umbilicated, pearly-white papules of the neck, trunk, eyelids; POX virus

217
Q

Molluscum Contagiosum Histological Presentation

A

cup-like epidermal hyperplasia, bright pink glassy cytoplasmic inclusions (molluscum bodies)

218
Q

Tinea capitus

A

fungal - scalp w. painful boggy nodules, hair loss, detect with Wood’s lamp

219
Q

Tinea barbae

A

fungal - beard area in men

220
Q

Tinea cruris

A

fungal - inguinal

221
Q

Tinea pedis

A

fungal - athlete foot (webs)

222
Q

Onchomycosis

A

fungal - nails, discolored & thickened

223
Q

Tinea Corporis

A

ring-worm - body surface, expanding, round, slightly red annular plaque

224
Q

Scabies

A

sarcoptes scabei burrows in stratum corneum - interdigital skin, genital skin (homeless)

225
Q

Lyme

A

spirochete infection (Borrelia burgdorferi) - annular lesions, erythema migrans

226
Q

Lice

A

Pediculosis capititis and pediculosis pubis

PATHOLOGY (18 decks)

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