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PATHOLOGY > Breast > Flashcards

Breast Flashcards

1
Q
A
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2
Q

Acute Mastitis

A

breast-feeding -> Staphylococcus aureus infection -> intramammary abscess

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3
Q

Periductal Mastitis

A

Smoker, reproductive age, painful mass, Squamous Metaplasia from nipple into ducts, keratin blocks ducts -> Granulomatous inflammatory reaction

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4
Q

Mammary Duct Ectasia Clinical Presenation

A

50-60 y/o, non-smoker, multiparous, cheesy nipple discharge, painless mass

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5
Q

Mammary Duct Ectasia Histological Presentation

A

Mucin-plug causing dilation of ducts filled with lipid-laden macrophages + granulomatous inflammation w/ infiltrate of lymphocytes, macrophages and plasma cells

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6
Q

Fat Necrosis

A

Trauma, lipid-laden macrophages, granulomatous inflammation, calcifications + crystallized lipid

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7
Q

Granulomatous Mastitis

A

Secondary to disease, infection, foreign body

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8
Q

Cyst Formation

A

PURE fibrocystic change; blue dome cysts, calcification, apocrine metaplasia

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9
Q

Fibrosis

A

PURE fibrocystic change; Cyst rupture -> overproduction of collagen -> fibrosis

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10
Q

Adenosis

A

PURE fibrocystic change; Fibrosis + aggregated glands w/ increased acini -> calcifications

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11
Q

Usual Ductal Epithelium Hyperplasia

A

Proliferation of ductal epithelium w/ no cytological changes, 2 cell types present

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12
Q

Atypical Ductal Epithelium Hyperplasia

A

Proliferation of ductal epithelium w/ cytological changes: mitotic figures, hyperchromia; Microcalcifications lining ducts (much like DCIS); Increased risk for cancer

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13
Q

Non-Complex Sclerosing Adenosis

A

Swirling fibrous tissue + increased acini + duct compression into cords

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14
Q

Complex Sclerosing Adenosis

A

Abundant central fibrosis / elastosis, Few, tiny glands separated by extensive bands of collagen

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15
Q

Atypical Lobular Epithelium Hyperplasia:

A

Proliferation of lobular epithelium w/ cytological changes: mitotic figures, hyperchromia

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16
Q

Sclerosing Papillomas

A

Typical sclerosing adenosis features + Papillary projections into lumen

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17
Q

Small Duct Papillomas

A

Occur deep w/in breast; Papilloma (arise from epithelium) in small ducts

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18
Q

Fibroadenoma

A

Most common neoplasm

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19
Q

Phyllodes

A

>60 y/o, large, low-grade tumor, less-defined, more cellular w/ few mitotic figures, SCALLOPED clefts

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20
Q

Cystosarcoma phyllodes

A

Highly CELLULAR, a lot of ATYPIA, less stromal tissue

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21
Q

Stewart-Trevis Syndrome

A

Lymphangiosarcoma may develop outside the breast in patients who have had mastectomy - lymphedema in unilateral UE

22
Q

Large Duct Papilloma

A

Serous or bloody nipple discharge; ductal papilloma in a large duct

23
Q

Ductal Carcinoma In Situ – Comedo

A

High-grade, high risk for IDC, solid sheets of tumor cells + central area of necrosis and microcalcifications

24
Q

Ductal Carcinoma In Situ – Comedo on mammogram

A

microcalcifications lining ducts

25
Q

Ductal Carcinoma In Situ – Non-Comedo

A

Low-grade, less atypia, characterized by the way cells grow in ducts (cribriform, papillary, etc)

26
Q

Paget Disease of the Nipple

A

Nipple is fissures, ulcerating, oozing; DCIS extends from nipple ducts into contiguous epithelium of nipple and areola

27
Q

Lobular Carcinoma In Situ

A

does not calcify or show up on mammogram, hard to detect, high incidence of BILATERALITY

28
Q

Invasive Ductal Carcinoma

A

Hard, gritty, chalky-like mass; • Cords, solid nests, anastomosing sheets of malignant cells

29
Q

African Americans tend to have

A

Triple negative IDC

30
Q

Medullary Carcinoma

A

IDC, 20-30y/o, BRCA1 mutation, HIGH-GRADE w/ LOW-GRADE BEHAVIOR; circumscribed, marked anaplasia + lymphocytic infiltrate

31
Q

Colloid/Mucinous Carcinoma

A

IDC, Elderly, well-circumscribed, mucin-lakes w/ malignant cell islands (PALE BLUE, gelatinous)

32
Q

Tubular Carcinoma

A

IDC, Low-grade, well-formed tubules, but lack myoepithelial cell layer, appears similar to Sclerosing Adenosis

33
Q

Invasive Papillary Carcinoma

A

IDC, rare, DCIS + papillary architecture

34
Q

Invasive Lobular Carcinoma

A

BILATERAL 20%, RUBBERY/scorrhous stroma, SINGLE-FILE Invasion; no tubules w/ rings about normal ducts

35
Q

cheesy discharge

A

Mammary Duct Ectasia

36
Q

blue dome cysts

A

Cyst Formation - fibrocystic change

37
Q

fibrous area b/w cysts that shows an aggregation of glands w/ enlarged lumens

A

Adenosis

38
Q

Proliferation of ductal epithelium + cytological changes

A

Atypical Ductal Epithelium Hyperplasia (DCIS)

39
Q

Swirling fibrous tissue, compression of ducts into cords + aggravated small glands

A

Sclerosing Adenosis

40
Q

Most COMMON neoplasm

A

Fibroadenoma

41
Q

glands forming flattened elongated /cleft-like spaces

A

Fibroadenoma

42
Q

GLAND spaces are more scalloped and may have breakdown of the epithelia

A

Phyllodes

43
Q

Serous or bloody nipple discharge

A

Large Duct Papilloma

44
Q

Nipple is fissured, ulcerating or oozing

A

Paget’s

45
Q

Hard, gritty, chalky-like mass

A

Invasive Ductal Carcinoma

46
Q

solid sheets of cancer cells

A

Invasive Ductal Carcinoma

47
Q

High-grade features w/ LOW-GRADE BEHAVIOR

A

Medullary Carcinoma

48
Q

Mucin lakes with malignant cell islands.

A

Colloid Carcinoma

49
Q

similar to Sclerosing Adenosis, tubules w/o myoepithelial cell

A

Tubular Carcinoma

50
Q

Rubbery, single-file

A

Invasive Lobular Carcinoma

51
Q

BILATERAL

A

Invasive Lobular Carcinoma

PATHOLOGY (18 decks)

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