Exam 8 Flashcards by Jennifer Becker

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24 yo female comes into ER. Vaginal spotting, history or PID, serum beta HCG increased and ultrasound shows suspicious mass in Fallopian tube. Where in the tube is this entity most likely located?

Ampulla

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female children of women exposed to DES are at risk of cancer, what type of cancer?

Vaginal clear cell

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Diagnosis from Vulvar biopsy lichen sclerosis heterotropism. Which is false?

Never seen in a woman under 30

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Which statement is correct regarding mulluscum contagiosum?

Pox virus

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You get a diagnosis from a vulvar biopsy: Bowens disease with mild dysplasia showing vin 1. What is wrong with this diagnosis?

High grade dysplasia process; severe dysplasia vin 3

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Vulvar biopsy shows Paget’s disease of the vulva. What’s the immunohistochemical staining pattern?

CEA pos, cytokeratin pos, p63 neg, S100 neg

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Vulgar biopsy: Malignment melanoma with superficial spreading, margins involved, breslows depth .67mm, negative for ulceration and lymphatic invasion. What immunohistochemical stains should be positive?

B and C (S100, melanin a(or MART-1))

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Vaginal biopsy changes consistent with Gartners duct cyst. It’s composed of cells from where?

composed of cells from the remnant Wolfian and mesonephric duct rests

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Vaginal biopsy embryonal rhabdomyosarcoma. What is true?

A and D (also known as sarcoma botryoides and histologic feature include a Cambian layer)

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Small cell carcinoma with neuroendocrine differentiation. Which of the following is not true?

CD 45 for LCA not positive Cytokeratin/81/83, synaptophysin, NSC (are all (+))

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Cervical biopsy shows mild dysplasia: CIN I.

Low grade intraepithelial lesion

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Which of the following is NOT a subtype of squamous cancer of the cervix?

Serous papillary

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Cervical biopsy endometrial adenocarcinoma grade 2/3 in the cervix. What is the staining pattern for endometrial cancer?

Vimetin pos, CEA neg, p16 neg, ERPR positive

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Early secretory endometrium day 17 (postovulatory day 3) Which is the characteristic histologic feature?

Subnuclear vacuoles lined up

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Endometrial biopsy: areas of stella phenomenon. What is the condition it is associate with?

Ectopic pregnancy

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Endometrial biopsy: Serous cancer of the endometrium. Which is the following is true?

Aggressive tumor associated with intraperitoneal spread

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Endometrial biopsy: malignant mixed mesodermal tumor (MMMT) carcinosarcoma. Which of the following statements is true?

Like Dedifferentiated endometrial cancer and has a fulminant clinical course

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Endometrial cancer staging summary. Which of the following statements is true for pt3b endometrial cancer?

Tumor extends into the vagina parametrial T3 is aggressive!!

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Endometrial Stromal sarcoma. What is the stain?

CD10

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Which of the following statements is true of polycyclic ovarian disease?

Also known as Stein-leventhal syndrome

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Pathological report reads 27 yo female of dysfunctional uterine bleeding and endometrial hyperplasia without atypia. Which of the statements is true?

Low grade hyperplastic process initially treated hormonally with progesterin therapy

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Path report of vaginal biopsy reads clear cell carcinoma grade 3 in a 24 yo female. Which of the following statements are correct?

Diethylstilbesterol (DES) exposure in the patients mother could be associated with this lesion

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WHO staging summary for Serous cyst adenocarcinoma confined to the pelvis with positive pleural effusion. Which of the following is true?

Stage 4

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Staging summary serous cyst adenocarcinoma. Which of the following is true?

Serous Borderline tumors with micro invasion have similar prognosis

Staging summary with mature teratoma prima ovari. What is wrong with the statement?

Not a mature teratoma

Endometrial Granulosis cell tumor of the adult type. What is true?

Estrogenic tumor effect

Sex cord stomal tumors with annular tubules.

Associated with peutz jaeger syndrome

Adenexal tumor of Wolfian duct origin. What is true?

Mesonephric origin

Small cell cancer of hypercalcemic type. What is true?

All the above

Sertoli Leydig cell tumor. What is true?

Masculinizing/androgenizing cell tumor

Mucinous adenocarcinoma of the endometrium. What is true?

Low grade neoplasm

Endodermal sinus tumor. Which of the following is not true?

Is not a seminoma

Rankes crystals.

Leydig cell tumor

Serous borderline tumors

Low malignant potential

Complete conjoined twins

Monochorionic and monoamniotic

Path report with diagnosis of complete hydatidiform mole. What's true?

Genotype 46 xx

Placental floor infarction

All of the above

TORCH titer

Toxo, syphilis, TB, listeria, rubella, CMV, and HSV

Complete mole.

Occurs in 1/10 pregnancies

Partial mole

Triploid

Invasive moles

All of the above

Uterine contents of gestational choriocarcinoma.

About 50% occur after molar disease

Changes associated in placental site trophoblastic tumor

Distinct membranous glomerulonephropathy

Placenta accreta

Complete adherence of decidua to muscle wall

Autopsy with cause of death as placental floor infarction

Misnomer, represents a fibrin deposition, not infarction

Acute chorioamnionitis and acute funisitis.

Ascending fetal infections, group b strep. and e.coli, associated with premature rupture of membranes, clinical signs are maternal fever All of the above?

Endometrial hyperplasia without atypia.

Low grade and low rate of progression

An endometrial biopsy expected to be day 23 but shows endometrial phase with glandular and stromal breakdown instead is indicative of what?

Anovulatory cycle DUB (dysfunctional uterine bleeding)

What is the endometrial carcinoma staging of a cancer that extends outside of the uterus but not into the true pelvis?

Stage 3

What is true of an adult granulosa cell tumor?

Cal Exner bodies and they’re associated w/ hyperestrogenism w/ feminizing effect

When the placenta implants over the cervix it is called:

Placenta previa

HPV strains causing high risk of cancer

HPV 16 and 18

Something about meconium staining

sign of fetal stress

Ovarian tumors - if the capsule (of ovary) is intact it is stage?

Ovarian tumors - if you have a metastasis to capsule (of liver) it's stage

Ovarian tumors - if it metastasizes to liver parenchyma (through capsule) it's stage

Serous cystadenocarcinoma of low malignant potential borderline tumor

absence of destructive invasion

Symptoms in malignant surface epithelial tumors

abdominal pain, increased girth, peritoneal implants and ascites (in ovarian unit)

Ovarian surface tumors of borderline malignant potential

peritoneal implants but no destructive invasion, histologically malignant but not destructive invasion (low grade malignant)

Mesothelial lesions in the peritoneum

Calretinin +