Skin Diseases Flashcards
What type of cell is skin?
Keratinized stratified squamous epithelium
Langerhans cell in skin ( brown parts )Histiocytes
Job is to recognize antigen
What is is acute Eczema?
Acute dermatitis
Acute eczema toys dermatitis
Edema/fluids splays keratinocytes and has a spongy look
Chronic Inflammatory dermatitis?
Psoriasis
Greek for Psoraisis?
The itch
what is Psoriasis?
CD4 and CD8 and growth factors
Hyper proliferation of the keratin
What is Ancanthosis?
Hyperplasia of the ancanthotic layer
What is parakeratosis?
Nucli come to the top of the skin
Psoriasis
The spines = ancanthosis
The nucli on top = parakeratosis
Greek for eczematous?
Boiling over
Seborrheic is what in Latin?
Tallow
What is seborrheic?
Barnacles on old people
Caused by fibroblast growth factor receptor
Never malignant
Verruca is Latin for what?
Wart
how do you get Verruca?
HPV
Cant become malignant
Undulant epidermal hyperplasia and koilocytosis (hollow)
How do you get acntinic Keratosis?
Sun exposure
Can regress to cancer
Basal cell hyperplasia
Dermal solar elastosis is what?
Makes you skin wrinkly
Actinic
What is basal cell carcinoma
Most common human cancer
Rarely metastasizes
PTCH pathway dysregulation
Basal cell carcinoma
Don’t grow up to be keratoniocies
What is a Squamous cell carcinoma?
Sun exposure but also burns and ulcers
Also from immunosuppression
Worse than basal cell but 5% can metastasize
Squamous cell carcinoma have keratin pearls
What is melanoma?
Mutation in proto-oncogenes and tumor suppressor genes
Where is melanoma worse?
New Zealand and and Australia bc Irish people
What goes bad in Melanoma?
Melanocytes gone bad
Melanoma
What is the ABCDE rule
A is asymmetrical
B is border
C is color variation
D - diameter bigger than a pencil erase 6cm
E - evolution does it change overtime
Melanoma
