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Human Disease AKA Nickey > Leukemias > Flashcards

Leukemias Flashcards

1
Q

what is the Greek for Leukos?

A

White and lymphomas

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2
Q

What is Maturation arrest?

A

You don’t grow up and stop a a certain place

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3
Q

What are the 2 things you need for leukemias?

A

Maturations arrest and duplication

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4
Q

What happens when bone marrow gets replaced?

A

Plugs up the pathway to produce normal cell elements

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5
Q

What stage does leukemias occur at?

A

Early stage is a blast, later on like bone marrow or blood or tissues (chronic lymphocytic leukemias)

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6
Q

Leukemias vs lymphoma

A

80 -85 % are B cell origins
Leukemias - grows in the bone marrows, marrow replacement ( anemia, infections and bleeding)
Lymphomas - painless masses ( always will we lymphocytes)

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7
Q

What is acute/chronic or lymphoid or myeloid leukemias?

A

Game of 4 square
Lymphoblastic or myeloid leukemia
Acute or chronic

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8
Q

What is Acute Lymphoblastic Leukemia?

A

70% of child leukemias
Get in blood and get into other organs

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9
Q
A

Lymphoblasts in the blood on the left
Bone marrow is filled with lymphoblast no balance on the right

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10
Q

What is Chronic lymphocytic leukemia?

A

Close to be normal lymphocytes
Grow very slowly
Small lymphocytic lymphoma
Live long time with it

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11
Q
A

Small mature lymphocyte and way to many in blood and bone marrow

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12
Q

What is Acute Myeloblastic leukemia?

A

Usually in older pt
WBC >100K

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13
Q

E

A

Cant tell just by looking but you can tell by stain that it is acute Myeloblastic leukemia

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14
Q

What is Chronic myeloid leukemia? Cells type? Age group?

A

Older people
WBC 170K
The cells are almost all mature and see a gradient of maturation only in chronic

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15
Q

What happens in Chronic Myeloproliferative disorders?

A

You mature cells keep replicating and replace all you blood cells and you get anemia

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16
Q

What is Hodgkin’s Lymphoma? Cell?

A

Reed sternberg cell hall mark
Started in 1 lymph then orderly spread

17
Q
A

Reed-Sternberg cell for Hodgkin’s disease ( the big thing in the middle)

18
Q

What is Follicular Lymphomas

A

40%
Mainly in older pts
Translocation of bcL-2 causes cell stay alive instead of apoptosis and build up
7-9 years living

19
Q
A

Follicular lymphoma

20
Q

What is small lymphocytes lymphoma?

A
21
Q

What is large B-cell lymphoma?

A

Highly aggressive and actively replicating
Chemo target the active replication
Unlike low grade and stage this can be cured

22
Q
A

Malignant B cell lymphocytes

Human Disease AKA Nickey (8 decks)

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