Leukemias Flashcards
what is the Greek for Leukos?
White and lymphomas
What is Maturation arrest?
You don’t grow up and stop a a certain place
What are the 2 things you need for leukemias?
Maturations arrest and duplication
What happens when bone marrow gets replaced?
Plugs up the pathway to produce normal cell elements
What stage does leukemias occur at?
Early stage is a blast, later on like bone marrow or blood or tissues (chronic lymphocytic leukemias)
Leukemias vs lymphoma
80 -85 % are B cell origins
Leukemias - grows in the bone marrows, marrow replacement ( anemia, infections and bleeding)
Lymphomas - painless masses ( always will we lymphocytes)
What is acute/chronic or lymphoid or myeloid leukemias?
Game of 4 square
Lymphoblastic or myeloid leukemia
Acute or chronic
What is Acute Lymphoblastic Leukemia?
70% of child leukemias
Get in blood and get into other organs
Lymphoblasts in the blood on the left
Bone marrow is filled with lymphoblast no balance on the right
What is Chronic lymphocytic leukemia?
Close to be normal lymphocytes
Grow very slowly
Small lymphocytic lymphoma
Live long time with it
Small mature lymphocyte and way to many in blood and bone marrow
What is Acute Myeloblastic leukemia?
Usually in older pt
WBC >100K
E
Cant tell just by looking but you can tell by stain that it is acute Myeloblastic leukemia
What is Chronic myeloid leukemia? Cells type? Age group?
Older people
WBC 170K
The cells are almost all mature and see a gradient of maturation only in chronic
What happens in Chronic Myeloproliferative disorders?
You mature cells keep replicating and replace all you blood cells and you get anemia
What is Hodgkin’s Lymphoma? Cell?
Reed sternberg cell hall mark
Started in 1 lymph then orderly spread
Reed-Sternberg cell for Hodgkin’s disease ( the big thing in the middle)
What is Follicular Lymphomas
40%
Mainly in older pts
Translocation of bcL-2 causes cell stay alive instead of apoptosis and build up
7-9 years living
Follicular lymphoma
What is small lymphocytes lymphoma?
What is large B-cell lymphoma?
Highly aggressive and actively replicating
Chemo target the active replication
Unlike low grade and stage this can be cured
Malignant B cell lymphocytes