Skin Cancer Prevention BCCA

Question 1

Most important malignancy amongst white populations in Europe NA and Australia

Answer 1

BCC

Question 2

BCC, most important environmental risk factor

Answer 2

Sunlight

Question 3

BCC risk factors

Answer 3

1. Light skin colour, red hair, tendency to burn.
2. Southern European ethnic origin lower risk
3. Freckling in children increases risk later in life
4. On recreational childhood exposure showed significant link to BCC later in life.
   5 Cumulative sun exposure did not show link to BCC
5. No association between degree of tanning and risk of BCC

Question 4

Most important environmental factor for SCC

Answer 4

Sunlight exposure

Question 5

Risk factors associated with SCC

Answer 5

1. Elevated risk in fair skin, red hair, burn easy.
2. Elevated risk in freckling.
3. Reduced risk in souther European ethnicity
4. Associated with 2 or > burns in childhood.
5. Strong trend with increasing occupation exposure in 10 years prior to dx
6. Risk with severe burns 1-2 per year in 10 years prior to Dx.
7. Sunburn frequency in intermediate years of life.
8. No relationship between degree of tanning and risk of SCC

Question 6

Sunscreen, how to apply

Answer 6

Skin should be white until sunscreen absorbed.

Question 7

Which wavelengths caused skin cancer

Answer 7

UVB

Question 8

Which is best blocker of UVA

Answer 8

Parasol 1789

Question 9

Sunscreens that block all UV light are …

Answer 9

Opaque blockers such as
titanium dioxide
Zinc oxide

Question 10

Broad spectrum sunscreens can prevent

Answer 10

Sunburn
Some aspects of photoaging
Actinic keratoses

Question 11

Melanoma risk factors

Answer 11

Environmental - sun exposure
Constitutional - fair hair, tendency to burn
Number of nevi is greatest risk factor

Question 12

Relationship between sun exposure and no. Nevi

Answer 12

Sunburn frequency up to 10 years showed strongest relationship with no nevi.
Sun exposed surfaces has higher nevi counts

Question 13

Studies of nevus in children

Answer 13

Boys develop > nevi than girls and number increases with age
Nevis density increases to age 14
More common in sun sensitive children
Higher counts with family history for skin cancer
Higher counts in children closer to equator

Question 14

Risk of developing skin cancer, melanoma

Answer 14

Any cancer 1:7

Melanoma 1:100

Question 15

Does outdoor workers or indoors workers with intermittent sun exposure have higher risk melanoma?

Answer 15

Indoor workers

Question 16

Wavelength of UVB

Answer 16

280 - 320

Question 17

Is UVB blocked by glass?

Answer 17

Yes

Question 18

Between UVB and visible light is …

Answer 18

Ultraviolet light

Question 19

Wavelength of ultraviolet A

Answer 19

320 - 400

Question 20

Which wavelength of UVA can damage DNA?

Answer 20

320 - 340 nm

Question 21

AVB as a broad band can cause

Answer 21

Some DNA damage
Photoaging
Tanning

Question 22

List risk factors for melanoma

Answer 22

Sun exposure
Fair skin
Congenital nevi
Dysplastic nevus syndrome
Family history - genetics are complicated. Most significant risk factor is dysplastic nevus syndrome

Question 23

Genetic risk factors for BCC

Answer 23

1, Nevoid basal cell carcinoma syndrome. Autosomal dominant. Hypertelorism and palmar pitting. jaw cysts and other abnormalities.
2. Xeroderma pigmentosum. Autosomal recessive.
Extreme sun sensitivity..