Module 8: Melanoma Flashcards
Diffuse reticular/ Patchy reticular - B v M
M - disorganized
Central hypo/ hyperpigmentation - B v M
M - off centre
Non- specific (structureless or featureless or homogenous) - B v M
M - heterogeneous hues or completely structureless
Peripheral globules and central reticular/ central globules and peripheral reticular - B v M
M - disorganized. Included asymmetric starburst
Globular - B v M
M - disorganized
Multi-component (symmetric)
2 component nevus
B v M
M Multi-component - 3 or more structures distributed asymmetrically
MM specific structures - sensitivity, 1-3
Regression structures
Atypical network
BWV
MM specific structures - specificity, 99% (4)
Streaks
Cystalline
BWV
Regression s
MM specific structures - odds ration, 1-4
Peripheral brown structureless
Crystalline
Atypical network
Regression structures
MM specific structures
- Atypical network (included grey angulated lines)
- Irregular Streaks (focal irregular - pseudopods & or radial streaming)
- Negative pigment network
- Crystalline (short white lines)
- Atypical dots and granules
- Atypical (irregular) blotch
- Blue white veil over raised areas
- Regression structures (BWV over flat area, peppering, scar)
- Atypical vessels
- Peripheral tan/ brown structureless areas
Atypical network is associated with ….
Superficial spreading melanoma
Angulated lines - description
Form zig zag pattern and polygonal structures (rhomboids)
Angulated lines Sens and Sp?
Not known but almost always MM
Angulated lines histopath correlation
NYD
Angulated lines most commonly seen
Sun damaged skin of face
Angulated lines also seen
Chronic sun damaged skin upper torso/ extremities
Histopath correlated irregular streaks/ pseudopods?
confluent junctional nests of pigmented melanocytes
confluent junctional nests of pigmented melanocytes associated with what type of growth
radial growth
confluent junctional nests of pigmented melanocytes associated with what type of melanoma …
superficial spreading
definition of negative network
serpiginous interconnecting hypo pigmented lines that surround irregularly shaped pigmented strcutures, which resemble elongated and curvilinear globules.
is pigment network seen with P or NP Dermoscopy?
both
In white benign lesions can you see negative pigment
- Spitz nevus.
2. CMN
Crystalline structures - definition
Short white lines only seen with polarizing Dermoscopy
Crystalline structures - cause
birefringent properties of collagen > polarized light to randomize it polarization rapidly
White reflective structures
- Crystalline (shiny white lines/ streaks) MM, spitz, LPLK
- Shiny white blotches/ patches/ areas (white clods) & strands BCC
- Rosettes AK, SCC, Actinic damaged skin
White reflective structures are predictive of ….
Thicker melanoma
Invasive melanoma