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Histopath > Skin > Flashcards

Skin Flashcards

1
Q

intercellular oedema

A

spongiosis

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2
Q

decreased cohesions between keratinocytews

A

acantholysis

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3
Q

linear pattern of melanocyte proliferation within epidermal basal cell layer

A

lentiginous

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4
Q

a group of disorders presenting with inflamed, dry, itchy rashes.
histology shows spongiosis and inflammatory inflitrates in the dermis in acute disease
and acanthosis, crusting and scaling in chronic disease.

A

Dermatitis/eczema

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5
Q

dermatitis seen in infanrs on the face/scal and in older pts on flexor surfaces. can cause lichenification if chronic

A

atopic dermatitis

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6
Q

type IV hypersensitivty dermatitis causing erythema, swelling and pruritis on contact with triggers

A

contact dermatitis

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7
Q

inflammatory reaction to a yeast - Malassezia - leading to large yellow scales in infants or mild erythema, mild scaling and pruritis on the face, eyebrown and eyelid of young adults.

A

seborrhoeic dermatitis

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8
Q

well demarcated red scaly plawues with silver scale affecting the extensor aspect of knees. can cause auspitz sign.

A

plaque psoriais

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9
Q

koebnor phenomenon

A

psoriatic lesions form at the site of traima

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10
Q

rain drop plaque dustribultion, often in children and can be seen 2 weeks post strep throat

A

guttate psoriasis

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11
Q

severe widespread diease with systemic symptoms. can be limited to the hands and feet.

A

erythrodermic/pustular psoriasis

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12
Q

nail changes in psoriasis

A

pitting
subungal hyperkeratosis
onycholysis

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13
Q

histology showing saw toothing of the rete ridges and basal cell degeneration

A

lichen planus

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14
Q

annular target lesions commonly on the extensor surfaces of the hands and feet. pleomorphic lesions -macules, papules, weals, vesicles…

A

erythema multiforme1

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15
Q

histology showing parakeratosis, clubbing of the rete ridges (test tube in rack appearance), munros microabcesses.

A

psoraisis

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16
Q

pruritic, purple, polygonal papules nad plaques with a mother of pearl sheen and wickams white line striae.

A

lichen planus

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17
Q

causes of erythema multiforme

A
  1. infection - HIV, mycoplasma

2. drugs - SNAPP - sulfonamides, nsaids, allopurinol, penicillin, phenytoin

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18
Q

IgG abs to the hemidesmosomes of the BM

A

pemphigoiD — hemiDesmosomes

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19
Q

desmoglyin abs

A

bullous foliaceus

20
Q

intraepidermal, superficial bullae form due to IgG abs against the desmosomal e-cadherin

A

PemphiguS

superficial

21
Q

large tense bullae on erythematous base, often on forearms, groin and axilla. Flexor surfaces. elderly pts.

A

pemphigoid

22
Q

easily rupture billae on skin and mucosal membrane. histology shows a netlike pattern of intercellular IgG deposits

A

pemphiguS

23
Q

acantholysis and destruction of e-cadherins

A

pemphiguS

24
Q

itchy vesicles found on extensor surfaces of the elows and buttocks, assocaited with coeliac disease

A

dermamtitis hepetiformis

25
Q

IgA abs to the basement membrane causing subepidermal bullae

A

dermatitis herpetiformis

26
Q

bullous diseas causing the stratum corneum to come off

A

foliaceus (the roof)1

27
Q

rough, waxy, stuck on appearance. histology shows horn cysts and thickening of basal keratinocytes

A

seborrhoeic keratosis

28
Q

rouch sandpaper like scaly lesions of sun exposed areas, histology shows solar elastosis, atypia/dysplasia, parakeratosis

A

actinokeratosis

29
Q

flat red scaly patches on sun exposed surfaces. histology shows full thickness atypia/dysplasia but the BM is still intact

A

Bowen’s disease

SCC in situ

30
Q

red scaly patches on the skin and spreading through the BM into the dermis. can wrap around nervers and cause damage..

A

SCC

31
Q

Slow growing tumour that is locally destructive., pearly with telangiectasia and central ulceration/punctum. rolled edge.

A

BCC

32
Q

subepidermal bullae with eopsinophils. immunofluorescence shows a linear deposition pattern of IgG + C3 along the BM

A

Pemphigoid

DDx - drug reaction, but wouldnt have C3.

33
Q

breslow thickness

A

prognostication factor for melanoma

34
Q

in what direction do the melanocytes migrate as they mature?

A

dwon - deeper into the skin.

keratinocytes move upwards

35
Q

pagetoid spread

A

upwards migration and enlargement of melanocytes, as seen in melanoma

36
Q

melanoma in sun exposed areas, common in elderly, flat slow growing black lesion

A

lentigo maligna

37
Q

irregular borders and variation in colour melanoma

A

superficial spreadingq

38
Q

melanoma common in young

A

nodular malignant melanoma

39
Q

melanoma occuring on the palms soles and subungal areas

A

acral lentiginous

40
Q

herald patch

A

pityriasis rosea

41
Q

nikolsky sign psotive

A

SJS/TEN

42
Q

sheets of skin detachment in <10% of body surface

A

SJS

43
Q

sheets of skin detachment in >30% of body surface

A

TEN

44
Q

common cause of SJS/TEN

A

Drugs - sulfonaminds, anticonvulsants, allopurinol.

AAS

45
Q

suspicious skin lesion, histology shows buckshot appearance and mitotic figures

A

melanoma

Histopath (13 decks)

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