Breast Flashcards
painful red breastwith fever. almost always occurs during lactation
acute mastitis
rx of mastititis
continue breast feed
abx
+/- surgical drainage
histology shows keratinising squamous epithelium that extends deep into nipple duct orifices. can cause painful red breast. NOT associated with lactation. often seen in smokers
periductal mastitis
poorly defined palpable periareola mass with thick white nipple secretions. can have painful nipple retraction.
occurs mainly in multiparous women in their 40-60s, benign.
mammary duct ectasia
inflammatory reaction to damamged adipose tissue leading to a painless breast mass
fat necrosis
group of breast changes caused by exaggerated response to normal hormonal fluctuations. presents with breast lumpiness.
fibrocystic disease/fibroadenosis
benign fibroepithelial tumour arising from the stroma
fibroadenoma
benign papillary tumour arising within the ductal system. causes bloody discharge but no lump. not seen on mammogram
duct papilloma
benign sclerosing lesion that resembles carcinoma on mamogram. central scarring surrounded by proliferating glandular tissue and stellate pattern.
radial scar
chromosomal abnormality seen in low grade BC and DCIS
16q deletion
neoplastic epithelial proliferation limited to the ducts/lobules by BM
carcinoma in-situ
always presents as an incidental finding on biopsy as has no microcalcificatioms/stromal reactions that can be seen on mammogram.
20-40% bilateral
RF for subsequent invasive breast cancer
LCIS
lack of e-cadherin
intraductal epithelial proliferation that appear as areas of microcalcifications on mammogram.
present with lump, discharge and pagets of the nipple.
increased risk of progression to BC
DCIS
lifetime risk of invasive breast cancer
1 in 8
breast cancer where cells are orgnaised into single file chains/strands
invasive lobular
