Skeletal Muscle Relaxants: Spasmolytic Agents

Question 1

4 conditions where spasticity is involved?

Answer 1

Spinal injury, cerebral palsy, MS, and stroke

Question 2

MOA of baclofen and effect?

1 adverse effect to know?

Answer 2

GABA b agonist which results in hyperpolarization and inhibition of excitatory NT release
Increased seizure activity in epileptic patients

Question 3

What is the MOA of carisprodol?
What are two adverse effects?
What is the control of the medicine?
What is the clinical application?

Answer 3

CNS depressant
Dizziness and drowsiness
4
Metabolized to meprobamate to treat anxiety

Question 4

What is the MOA of diazepam?
4 effects/clinical uses?
What scheduled medication is it?

Answer 4

Long acting benzo
Increases GABA inhibition
Sedation, muscle relaxation, anti anxiety and anticonvulsant
4

Question 5

Clinical application of cyclobenzaprine?

Answer 5

Muscle pain and stiffness

Question 6

MOA of tizanidine?

Answer 6

Alpha 2 agonist which drops excitatory input to alpha motor neurons

Question 7

MOA of dantrolene?

2 clinical uses?

Answer 7

Inhibition of ryanodine receptor and blocks calcium rerelease so contraction is impaired. Cardiac and smooth muscle is not affected.

Upper motor neuron disorders and malignant hyperthermia

Question 8

MOA of botulin toxin?

Answer 8

Cleaves SNARE so Ach is not released

Question 9

3 adverse effects of cyclobenzaprine?

Answer 9

Drowsiness, dizziness, and xeostomia

Question 10

Clinical application of glucos?

Answer 10

MS

Question 11

MOA of glatiramer acetate?

Answer 11

Polymer similar to myelin basic protein that induces T cell suppressor cells

Question 12

MOA of interferons?

Clinical effects?

Answer 12

Blocking T cell adhesion on BBB
Reduced number of T2 lesions
Slowing of brain atrophy

Question 13

MOA of mitoxantrone?

3 clinical applications?

Answer 13

Cross links and DNA strand breaks

Treat MS, AML and prostate cancer