DERM 2 - Psorias, ACNE, And Ectoparasitic Infections

Question 1

What is initial choice for mild to moderate psoriasis as far as topical therapies?

Answer 1

Emollients and corticosteroids

Question 2

What is a good initial choice for moderate to severe psoriasis?

Answer 2

UVB

PUVA

Question 3

MOA of apremilast and effect?
2 Clinical applicaiton?
Administration?

Answer 3

Blocks PDE4 which increases cAMP levels which leads to lowered NOS, TNF, and IL23 and increases Il10

Moderate to severe psoriasis and psoriatic arthritis

Orally

Question 4

MOA for ustekinumab?
3 clinical applications?
1 adverse effect?

Answer 4

Antibody against IL12 and 23
Psoriasis, psoriatic arthritis, and Crohns
Increased risk for infections

Question 5

MOA of secukinumab and Ixekuzumab?
3 clinical uses?
Adverse effect?

Answer 5

Antibody against 17A
AS, psoriasis and psoriatic arthritis
Infections

Question 6

First choice treatment for mild acne comedones only?
Mild with papules/pimples?
Moderate with papules/pimples?
Moderate with nodular scarring?
Severe with nodular?

Answer 6

Topical retinoid
topical retinoid + topical antimicrobial
Topical retinoid + oral antibiotic +- BPO
Topical retinoid + oral antibiotic + BPO
Oral isoretinoin

Question 7

MOA of tretinoin?
Clinical use?
Adverse effect?

Answer 7

Topical retinoid
Mild acne, no papules
No if allergy to fish

Question 8

3 topical antimicrobials to know and their clinical use?

Answer 8

Benzoyl peroxide, clindamycin, and erythromycin

Mild acne

Question 9

MOA and effect of azaleic acid?

2 clinical uses?

Answer 9

Kills acne bacteria and decreases production of keratin

Mild to moderate acne and post inflammatory hyperpigmentation

Question 10

6 oral antibiotics commonly used for acne and what is their specific clinical use?

Answer 10

Tetracycline, doxycycline, Minocycline, erythromycin, azithromycin, and TMP/SMX
Moderate acne

Question 11

What is a notable adverse effect of tmp/SMX?

Answer 11

Steven Johnson syndrome and toxic epidermal necrolysis

Question 12

What is an alternative for females to add to their treatment regimen when they have moderate acne and why?

Answer 12

Hormonal therapy because they can have cycle induced break outs

Question 13

2 drugs to give to females for hormonal related acne?

Answer 13

Oral contraceptives

Spironolactone

Question 14

MOA of isoretinoin?
Clinical use?
Adverse effect?

Answer 14

Oral retinoid
Severe acne
Teratogenicity, absolutely contraindicated in pregnancy

Question 15

What is the clinical sign for inflammatory acne?

Answer 15

Hyperpigmentation

Question 16

Capsaicin activates which channels?

Menthol cools via what receptors?

Answer 16

TRPV1 heat channels

TRPM8

Question 17

MOA of the following agents to kill ectoparasites?
Malathion?
Permethrin?
Ivermectin?
Lindane?

Answer 17

Cholinesterase blocker
Blocks insect sodium channels
Blocks glutamate chloride channels in bugs
Disrupts GABAergic in bugs

Question 18

Two clinical uses of calcineurin blockers?

Answer 18

Psoriasis and itching