Gout Flashcards
1
Q
3 things the MSUS crystals do to cause inflammation?
A
Endothelial activation via IL1 and TNF
Macrophage activation and then IL8 to get neutrophils
Complement
2
Q
Three common places for gout even tho it can happen in any joint?
A
Feet, ankles and knees
3
Q
3 ways to consider treating gout and what specific drugs to accomplish it?
A
NSAID and colchicine for inflammation and crystal deposit
Allopurinol or febuxostat for xanthine blocking
Probenecid to promote excretion
4
Q
Colchicine must be given how close to the start of an acute gout attack to be effective?
A
Within 24 hours
5
Q
What joints are more commonly affected by pseudogout?
A
Large joints, knee
6
Q
What patient population to think of with pseudogout?
Treatment?
A
Older
NSAIDS, colchicine, and steroids
