DERM 3 - Pruitis, Antibacterial, Fungal And Viral

Question 1

4 non pharm treatments for itching?

Answer 1

Keeping skin moist, cool environment, avoid known skin irritants and reduce stress.

Question 2

How does topical corticosteroids help witch itching?
What is topical calcineruin blockers particularly use for with itching?
Capsaicin is particularly useful with what type of itching?
Local anesthetic pramoxine and lidocaine patch are useful in what itching respectively?
Salicylic acid itching use?

Answer 2

It’s not anti itch but it takes out the inflammation that might be causing it
Anogenital itching
Neuropathic itching
Itching on face and CKD itching
Neuropathic itching
lichen simplex chronicus

Question 3

Don’t use doxepin in what patient population?

Answer 3

Children

Question 4

What 3 areas of the body do we use low potency steroid use?

Answer 4

Face, genitals and skin folds

Question 5

Antidepressants work in what type of itching?
Mu Opioid antagonists work in what type of itching?
kappa opioid antagonists work in what type of itching?
Anticonvulsants like gabapentin work in what type of itching?

Answer 5

Nocturnal and cholestatic
Cholestatic and CKD
Nocturnal
Neuropathic

Question 6

MOA and clinical use of brimonidine?
MOA and clinical use of oxymetazoline?
What is the MOA for eye drops getting rid of redness?

Answer 6

Alpha 2 agonist for Rosacea

Adrenergic agonist

Question 7

What is the MOA of imidazoles and what two things do they treat?
Clinical use for miconazole?
Clinical use for clotrimazole?
Clinical use for efinaconazole?
3 clinical uses for ketoconazole?

Answer 7

Block ergosterol synthesis
Dermatophytes and yeasts

Vulvovaginal candidiasis
Vulvovaginal candidiasis
Onychomycosis
Dermatophytosis, candidiasis, and seborrheic dermatitis

Question 8

MOA of ciclopirox and activity against what 3 things?
MOA of terminating and activity against what 1 thing?
MOA of tolnaftate and activity against what 2 things?

Answer 8

Macromolecular blocker dermatophyte, candida, and malassezia
Squalene epoxidase inhbitor and dermatophytes
Dermatophytes and malessezia

Question 9

MOA of nystatin and pathogen?

MOA of amphotericin B and pathogen?

Answer 9

Alters membrane permeability and skin and mucosal candida

Alters membrane permeability and candida

Question 10

MOA of acyclovir and clinical use?

Answer 10

Guanine analog blocking HSV1 and 2 activity

Recurrent orolabial HSV in immunocompetent adults

Question 11

Clinical use for fluconazole and itraconazole regarding skin infections?
Clinical use for terbinafine for skin infections?

Answer 11

Tinea versicolor

Onychomycosis

Question 12

MOA of bacitracin and clinical use?
MOA of neomycin and clinical use?
MOA of polymixin B and clinical use?

Answer 12

Blocks bacterial cell wall synthesis gram positive
Blinds 30s subunit and inhibits protein synthesis, gram negative
Damages bacterial membrane gram negative including PA, E COli kleb

Question 13

MOA of becaplermin, clinical use and black box warning?

Answer 13

PDGF that promotes cell growth and BV growth
Only agent approved for chronic diabetic foot ulcers
Malignancy

Question 14

3 phase of wound healing?

Answer 14

Inflammatory, proliferative and remodeling

Question 15

2 general principles for wound dressing?
What to use for debridement stage?
Granulation stage?
Epithelization stage?

Answer 15

Keep wound moist and not exposed to air

Hydrogels
Foam and low adherence dressings
Hydrocolloid and low adherence dressing s

Question 16

MOA of the following antiseptics?
Glutaraldehyde?
Quaternary amines?
Chlorhexidine?
Halogens?
Peroxygens?

Answer 16

Cross linking proteins
Membrane damager
Membrane damager
Oxidize thiol groups
Hydrogen peroxide

Question 17

MOA of chlorohexidine and clinical use?

Answer 17

Antiseptic and disinfectant for skin of patients and providers before and after surgery. Works on oral mucosa too.

Question 18

What is the MOA of biofilms in resisting antibiotics?

Answer 18

Bacteria attach to a surface and grow as a biolfilm and are protected from antibiotics. They can neutralize and not be penetrated by antibiotics

Question 19

Clinical use of griseofulvin? 2 pathogens it is not effective against?

Answer 19

Dermatophytes on the scalp

Candidia and mallessezia