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Clinical MSK > Clinical Serology And Lab Testing. > Flashcards

Clinical Serology And Lab Testing. Flashcards

1
Q

ESR rises with what and is higher in which gender?

ESR is used to monitor disease activity in which two diseases particularly?

A

Age and female

PMR and GCA

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2
Q

What value of CRP is diagnostic for inflammation?

A

Greater than 8mg

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3
Q

RF is present 100% of the time in what type of RA?

A

Nodular RA

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4
Q

6 other conditions bedsides RA that RF is present?

A

Sjogren, cryoglobuinemia, primary biliary cirrhosis, mixed connective tissue, endocarditis, and lupus

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5
Q

What value of RA is positive by ELISA?

What value of RA is positive by latex fixation?

A

Over 45

Over 1:80

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6
Q

2 antibodies specific for RA?

A

RF and CCP

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7
Q

Homogenous pattern of ANA indicates which disease?
Speckled anti SM indicates which disease?
Speckled anti SSA and SSB indicates which disease?

A

Drug induced lupus
Lupus
Sjogren

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8
Q

What is the mnemonic for SLE diagnostic criteria and what does each letter stand for?

A

A RASH POINts MD
Arthritis, renal disease, ANA positive, Serositis (lung or heart), hematology disorders, photosensitivity, oral ulcers, immunological disorders, Neurological disorders, Malar rash and Discoid rash.

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9
Q

What are the 2 renal disorders we are looking for in the criteria?
What are the 2 neurologic disorders?
4 hematologic disorders?

A

Protein in the urine or casts
Seizures or psychosis
Hemolytic anemia, leukopenia, lymphopenia, and thrombocytopenia

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10
Q

3 immunological labs for lupus criteria?

A

Anti DNA, Anti SM, false positive RPR test for syphilis

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11
Q

What two antibodies does the body produce against group A strep infections?
What two conditions can come after a strep infection that is relevant?

A

ASO and anti DNAase b

Acute rheumatic fever and arthritis.

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12
Q

2 patient populations we most commonly see gout?

A

Men in 4th to 6th decade

Post menopausal women

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13
Q

3 things to treat acute gout?

3 things to treat chronic gout?

A

NSAIDS, colchicine, and steroids

Xanthine oxidase blocker, uricouric drugs, and probenecid

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14
Q 
How many joints are involved with the following prefixes?
Mono
Oligo
Pauci 
Poly
A

1
3 or less
5 or less
6 or less

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15
Q

4 conditions under the category of arthritis - bowel?

A

UC, Crohns, Behcets, Reactive arthritis because of bowel infection

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16
Q

5 physical exam signs of arthritis -pulmonary?

A

Clubbing, nodules, effusions, hilar nodes and infiltrates

17
Q

2 manifestations of inflammation due to arthritis in diabetes?
1 manifestation of inflammation in thyroid?

A

Charcots and cheiroarthropathy

Carpal/tarsal tunnel syndrome

18
Q

2 manifestations of retinopathies to know?

A

Cytoid bodies and vasculitis

19
Q

What are 5 things that are elevated in inflammation?

A

Leukocytosis, thrombocytosis, ferritin, fibrinogen and complement

Clinical MSK (16 decks)

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