NMJ Disorders

Question 1

3 clinical symptoms of M gravis?

Answer 1

Fluctuating weakness
Distribution of weakness
Clinical response to cholinergic drugs

Question 2

4 lab findings supporting M gravis?

Answer 2

ACHR antibodies
Musk antibodies
EMG findings show progressive weakening on continued stimulation
Positive Endrophonium test

Question 3

What family of antibiotics can cause M gravis?

Answer 3

Aminoglycosides

Question 4

What are the 3 types of MUSK syndrome? What is musk syndrome?

Answer 4

These patients lack antibodies against ACHR and have MUSK antibodies. Mainly in women.
Oculpharyngeal weakness
Neck, shoulder, respiratory weakness
Indistinguishable from antibody positive MG

Question 5

What is Lambert Eaton often associated with?

Answer 5

SCCL

Question 6

5 clinical signs of Lambert Eaton?

Answer 6

Proximal muscle weakness, loss of deep tendon reflexes, myalgia, dry mouth and impotence

Question 7

3 lab findings for Lambert Eaton?

Answer 7

Antibodies against VGCC
Low amplitude motor response that increases after exercise
Incremental response after repetition stimulation