Sjogren's Syndrome

Question 1

what type of condition is this

Answer 1

autoimmune

Question 2

what characterises Sjogrens

Answer 2

lymphocytic infiltrates in exocrine glands

Question 3

what are some symptoms

Answer 3

dryness of eyes and mouth (sicca symptoms), arthralgia, fatigue, vaginal dryness, parotid gland swelling

Question 4

how does this occur

Answer 4

as a primary condition or secondary to other autoimmune conditions

Question 5

what can occur due to Sjogrens

Answer 5

peripheral neuropathy, interstitial lung disease and increased risk of lymphoma

Question 6

how is this diagnosed

Answer 6

confirmation of ocular dryness (schirmers test), positive anti-Ro and anti-La antibodies and typical features on a lip gland biopsy

Question 7

how many of the American-European Consensus Group classification criteria are needed for diagnosis

Answer 7

4/6

Question 8

how is this managed

Answer 8

largely symptomatic
eyedrops, saliva replacement products, dental care due to risk of caries, pilocarpine (can stimulate saliva production but often causes side effects e.g flushing), hydroxychloroquine for arthralgia and fatigue, immunosuppression for organ involvement