Dermatomyositis Flashcards
what is dermatomyositis
polymyositis but with skin involvement
who is dermatomyositis seen in
women 2:1
adults over 20 esp 45-60
what percentage of patients have an autoimmune response to nuclear and cytoplasmic autoantigens
60-80%
what serum autoantibodies are shared with other autoimmune conditions
ANA and anti-RNP antibody
what serum autoantibodies are unique to dermatomyositis
anti-Jo-1 and anti-SRP. autoantibodies
what is different to polymyositis
additional cutaneous features
what are the cutaneous features
V shaped rash, Gotttron’s papules, heliotrope rash
what is the associated risk of malignancy
25%
when is the risk for malignancy greatest
5 years following diagnosis
malignancy should be screened for at the time of diagnosis
what common are the common cancers
breast, ovarian, lung, colon, oesophagus and bladder
