Signals Flashcards
apoptosis: death
BMP, TNFalpha, FAS ligand, TRAIL
initiate sympathetic neuronal development
BMP from aorta
specify embryonic epidermal fate from neuroectoderm
BMP, Wnt
specify stratified epidermis from embryonic epidermis
BMP, Notch
apoptosis: survival
FGF
maintain caudal growth, segment rostral
FGF and Wnt gradient from caudal end
limb initiation
FGF and Wnt
Proximal-distal limb patterning
FGF from AER
limb outgrowth
FGF from AER
specify neuronal fate from neuroectoderm
FGFs and BMP inhibitors
A/P axis: posterior
Nodal and Wnt
A/P axis: anterior
nodal and wnt inhibitors (DKK?)
L/R determination
nodal flow, nodal and lefty
Initial dorsal/ventral patterning:
SHH (from notochord, patterns neural plate)
cause ventral somite to be sclerotome
Shh and noggin (BMP inhibitor) from notochord and floor plate
A/P limb patterning
SHH from ZPA (more SHH, more posterior)
patterning ventral ID in nervous system
More SHH ventrally, More BMP dorsally
regulate follicle development
SHH, Wnt
induce dermamyotome
Wnt and noggin (from dorsal neural tube), low SHH
dorsal/ventral limb patterning: dorsal
Wnt and Lmx1
separate nonneural ectoderm from neural plate during induction
Wnt (paracrine), BMP (from neuroectoderm), FGF (from paraxial mesoderm)
specify hair and nails from embryonic epidermis
Wnt
head formation
Lhx1 (from anterior visceral endoderm and axial mesoderm)
segmentation clock
notch (w/Hes and Lfng)
