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MM Development > Development Signalling Pathway Summary > Flashcards

Development Signalling Pathway Summary Flashcards

1
Q

Hedgehog ligands

A

Shh, Ihh, Dhh

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2
Q

Hedgehog receptor

A

Ptch

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3
Q

Hedghog transducer

A

Smo

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4
Q

Hedgehog output

A

Gli 1,2,3

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5
Q

Hedgehog mode

A

ligand binding inhibits ptch inhibition of Smo, so inihibitory Gli (3) is replaced by stimulatory Gli (1 and 2). Ratio of repressor to activator determines magnitude of output

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6
Q

Wnt ligand

A

20 Wnt

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7
Q

Wnt receptor

A

Frizzled (7)

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8
Q

Wnt transducer

A

Beta catenin

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9
Q

Wnt output

A

beta catenin & TCF/Lef

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10
Q

Wnt mode

A

cytoplasmic s/t phosphorylation complex targets beta catenin for destruction. If lignad binds, beta catenin is not degraded and goes to nucleus

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11
Q

TCF/Lef

A

transcription factor family turned on by beta catenin in the nucleus

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12
Q

TGFb/BMP ligands

A

> 20 TGFb/BMPs

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13
Q

TGFb/BMP receptor

A

Alk1-7

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14
Q

TGFb/BMP transducer

A

Smad

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15
Q

TGFb/BMP output

A

Smad

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16
Q

TGFb/BMP mode

A

lingand binds heterotrimeric S/T kinase receptor, causes phosphorylation of positive Smads, which multimerize with a coSmad and go to nucleus

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17
Q

TGFb/BMP stands for

A

transforming growth factor beta/bone morphogenic protein

18
Q

FGF ligand

A

> 20 FGFs

19
Q

FGF receptor

A

FGFR1-4

20
Q

FGF transducer

A

Mapk cascade

21
Q

FGF output

A

Erk

22
Q

FGF mode

A

Ligand binding stimulates s/t kinase, leading to recruitment of adapter proteins that initiate s/t Mapk csacade, resulting in Erk which goes to nucleus.

23
Q

MAPKKK cascade

A

MAPKKK(Ras/Raf cx) → MAPKK (Mek) → MAPK (Erk)

24
Q

FGF stands for

A

fibroblast growth factor

25
Q

Notch/delta ligand

A

3-4 delta-like

26
Q

Notch/delta receptor

A

Notch 1-4

27
Q

Notch/delta transducer

A

Notch intra

28
Q

Notch/delta output

A

Cbf1

29
Q

Notch/delta mode

A

(tehtered) ligand binding leads to intracellular cleavage of N receptor, which translocates to the nucleus and interacts with Cbf1 to regulate target genes

30
Q

RA ligand

A

retinoic acid

31
Q

RA receptor

A

RAR/RXR

32
Q

RA transducer

A

RAR/RXR

33
Q

RA output

A

RAR/RXR

34
Q

RA mode

A

A is lipid soluble, freely diffuses, binds nuclera RAR/RXR heterodimers and converts them from repressors to activators

35
Q

RA stands for

A

retinoic acid

36
Q

Eph/ephrin ligand

A

ephrin A/b (8)

37
Q

Eph/ephrin receptor

A

EphA/B (14)

38
Q

Eph/ephrin transducer

A

MAPK cascade, cytoskeleton

39
Q

Eph/ephrin output

A

MAPK cascade, cytoskeleton

40
Q

Eph/ephrin mode

A

bidirectional, both ligand and receptor can be mebrane associated. Does MAPK and exerts adhesive or guidance functions by modulating cytoskeleton stability

MM Development (9 decks)

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