sideroblastic anaemiaa

Question 1

what is the definition of sideroblastic anaemia?

Answer 1

1. anaemia caused by defective haem metabolism

2. iron trapping inside the mitochondria

Question 2

What are the inherited causes of sideroblastic anaemia?

Answer 2

1. X linked sideroblastic anaemia due to alpha-ALA-sythase gene

Question 3

What are 3 acquired causes of sideroblastic anaemia?

Answer 3

1. vitamin B6 deficiency
2. Lead poisoning
3. Alcohol use disroder

Question 4

Iron studies results

Answer 4

1. high ferritin
2. high iron ( only anaemia with elevated iron)
3. high transferrin sat
4. normal/low TIBC

Question 5

What is seen on bone marrow staining?

Answer 5

ringed sideroblasts

Question 6

Tx of sideroblastic anaemia

Answer 6

1. cessation of offending agent

2. Pyridoxine (B6) supplementation