sickle cell anaemia

Question 1

what is the pathophysiology of sickle cell anaemia?

Answer 1

1. beta globin chain misshapen due to defect in beta globin gene
2. red blood cells have elongated sickle appearance
3. intravascular haemolysis

Question 2

how is sickle cell anaemia inherited?

Answer 2

autosomal dominant

Question 3

sickle cell disease - genes

Answer 3

1. mutation in HBBs gene

2. mutation in HBBs gene

Question 4

sickle cell trait - genes

Answer 4

1. mutation in HBBs
2. normal HBB gene

( only carrier, mainly assymptomatic)